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Gut microbiota of patients insusceptible to olanzapine-induced fatty liver disease relieves hepatic steatosis in rat.

Am J Physiol Gastrointest Liver Physiol

December 2024

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Olanzapine-induced fatty liver disease continues to pose vital therapeutic challenges in the treatment of psychiatric disorders. In addition, we observed that some patients were less prone to hepatic steatosis induced by olanzapine. Therefore, we aimed to investigate the role and the underlying mechanism of the intestinal flora in olanzapine-mediated hepatic side effects and explore the possible countermeasures.

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The gut-brain-metabolic axis has emerged as a critical area of research, highlighting the intricate connections between the gut microbiome, metabolic processes, and cognitive function. This review article delves into the complex interplay between these interconnected systems, exploring their role in the development of insulin resistance and cognitive decline. The article emphasizes the pivotal influence of the gut microbiota on central nervous system (CNS) function, demonstrating how microbial colonization can program the hypothalamic-pituitary-adrenal (HPA) axis for stress response in mice.

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The gut microbiota-brain connection: insights into major depressive disorder and bipolar disorder.

Front Psychiatry

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Department of Critical Care Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, China.

Major depressive disorder (MDD) and bipolar disorder (BD) are two of the most prevalent mood disorders that seriously jeopardize both physical and mental health. The current diagnosis of MDD and BD relies primarily on clinical symptoms. However, correctly differentiating between MDD and BD during depressive episode states remains a substantial clinical challenge.

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Human-fecal microbiota transplantation in relation to gut microbiome signatures in animal models for schizophrenia: A scoping review.

Asian J Psychiatr

December 2024

Schizophrenia Division, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Banting and Best Diabetes Centre (BBDC), Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Article Synopsis
  • Recent research is exploring how the gut microbiome (GMB) may influence schizophrenia (SCZ), including its development, symptoms, and treatment responses.
  • Studies indicate that the GMB composition in animal models of SCZ differs from control groups and correlates with SCZ-like behaviors.
  • Fecal microbiota transplantation (FMT) from SCZ patients to rodents has shown altered brain functions and behaviors similar to those seen in SCZ, suggesting these models may help deepen our understanding of the disorder, though further validation is needed.
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Arabic validation of the Body-Esteem Scale for Adolescents and Adults.

Encephale

October 2024

University Tunis El Manar, Faculty of Medicine of Tunis, rue Djebal Lakhdar, 1006 Tunis, Tunisia; Child Psychiatry Department, Mongi Slim Hospital, Sidi Daoud, 2046 Tunis, Tunisia; Research Laboratory "Laboratoire Santé Mère-Enfant LR22SP01", Tunis, Tunisia.

Objectives: The aim of this study was to validate the questionnaire "Body-Esteem Scale for Adolescents and Adults" (BESAA).

Methods: We conducted a cross-sectional study involving 340 adolescents who attend a Tunisian high school. We translated the BESAA into dialectal Tunisian Arabic based on the translation back-translation method.

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