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Case report: Successful treatment of hyperkalemia during general anesthesia in a domestic cat.
Front Vet Sci
August 2024
Emergency Critical Care Department, DoveLewis Veterinary Emergency & Specialty Hospital, Portland, OR, United States.
Objective: This study aimed to describe the successful identification and treatment of severe hyperkalemia, cardiac arrhythmia, rhabdomyolysis, and acute kidney injury (AKI) in a domestic cat that underwent general anesthesia for abdominal exploratory surgery. The definitive underlying cause remains unknown; however, a reaction to propofol is suspected.
Case Summary: A 6-month-old intact male domestic short-hair cat underwent general anesthesia and developed severe intraoperative rhabdomyolysis, hyperkalemia, ventricular fibrillation, and AKI during surgery despite a documented mild hypokalemia and normal creatinine before inducing anesthesia.
Safety of Extended Propofol Infusions in Critically Ill Pediatric Patients.
Cureus
May 2024
Pediatrics, University of Florida College of Medicine, Gainesville, USA.
Introduction Propofol is a phenol agent with sedative and anesthetic properties that has been in use for decades, but with controversy in critically ill pediatric patients, given the concern for developing propofol-related infusion syndrome (PRIS). Our aim was to assess the risk of propofol infusions in the pediatric intensive care unit (PICU) at doses and durations greater than the described safety data and its associated covariables. Methods Retrospective cohort analysis of 173 patients receiving propofol in the PICU.
View Article and Find Full Text PDFClinical observation: Rhythmic and periodic EEG patterns in postanoxic coma can possibly be related to propofol discontinuation.
Resuscitation
August 2024
Amsterdam UMC, University of Amsterdam, Department of Neurology and Clinical Neurophysiology, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, Netherlands. Electronic address:
Objectives: To investigate whether rhythmic/periodic EEG patterns (RPP) appearing after propofol discontinuation are more likely to be related to the elimination phase of propofol, or are an expression of severe brain damage.
Methods: In a retrospective cohort of comatose postanoxic patients, EEG was assessed one hour before (baseline) and on hour after discontinuation of propofol. Presence and duration of RPP were related to (changes in) EEG background pattern and duration of sedation.
Propofol Infusion Syndrome Following Endoscopic Tracheoplasty and Jet Ventilation: Case Report.
Ann Otol Rhinol Laryngol
April 2024
Department of Otolaryngology, University of Missouri, Columbia, MO, USA.
Objective: We present a case of propofol infusion syndrome (PRIS) following jet ventilation.
Method: Case report and review of literature.
Results: A 70-year-old man required CO2 laser endoscopic tracheoplasty for tracheal and subglottic stenosis due to A-frame deformity.
Characterization of Propofol Use For Non-Procedural Sedation in a Pediatric Intensive Care Unit.
J Pediatr Pharmacol Ther
December 2023
Department of Pharmacy (JB, BC, MMM), Texas Children's Hospital, Houston, TX.
Objective: Given the limited literature describing propofol use in pediatric patients, this study aimed to describe the dosing and duration of propofol infusions for non-procedural sedation in the pediatric intensive care unit (PICU). The secondary objectives were to describe the change in concomitant sedative requirements from the 24-hour period before propofol initiation to the 24-hour period after discontinuation of propofol and to review the frequency of adverse events.
Methods: This retrospective descriptive cohort study evaluated children 1 month to less than 18 years old who received a continuous infusion of propofol for non-procedural sedation in the PICU between May 2018 and August 2020.
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