Backgrounds/aims: This study aimed to evaluate clinical application of InnoSEAL Plus (a mussel-inspired catecholamine hemostat) as a new hemostatic material for humans.
Methods: Patients treated with topical hemostatic patches after liver resection were enrolled. They were divided into an experimental group (InnoSEAL Plus group) and two control groups (TachoSil group and Surgicel Fibrillar group) for efficacy evaluation.
Results: A total of 15 patients were enrolled. Each group had five patients. The 3-minute hemostasis success rate was 80.0% (4/5 patients) in the InnoSEAL Plus group, 80.0% (4/5 patients) in the TachoSil group, and 40.0% (2/5 patients) in the Surgicel Fibrillar group, showing no significant difference in the success rate among these groups ( > 0.05). All three groups exhibited 100% success rate for 10-minute hemostasis. Both InnoSEAL Plus and TachoSil groups had one patient developing adverse events, which were treated easily with drug administrations.
Conclusions: InnoSEAL Plus is expected to be functionally not inferior to other conventional hemostatic agents. However, it is necessary to confirm this through multicenter prospective studies in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901974 | PMC |
| http://dx.doi.org/10.14701/ahbps.21-077 | DOI Listing |
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