AI Article Synopsis
- - This paper focuses on creating a fluorescent probe using meso-carboxysubstituted-BODIPY combined with a thioterpene fragment to examine the antiplatelet and anticoagulant effects of thioterpenoids.
- - The researchers replaced a methoxy group in the BODIPY molecule with the thioterpene fragment to better understand the interactions of these compounds with membranes and receptors.
- - The newly designed probe exhibits a high fluorescence quantum yield near 100% in the blue-green range (509-516 nm) and shows improved affinity to the platelet receptor P2Y through molecular docking studies.
Article Abstract
This paper is devoted to the design of a fluorescent probe based on meso-carboxysubstituted-BODIPY with a thioterpene fragment. The functional replacement of the methoxy group in the BODIPY molecule on a thioterpene fragment was carried out in order to find out the antiplatelet and anticoagulant action mechanisms of thioterpenoids and to assess the membrane and receptor factors contributions. The molecular structure of the conjugate was confirmed via UV/vis-, NMR- and MS-spectra. It is found that the probe is a high fluorescence quantum yield (to ∼ 100%) in the blue-green region at 509-516 nm. Molecular docking of all studied molecules showed that the BODIPY with terpenoid conjugation is an excellent way to increase their affinity to platelet receptor P2Y.
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| http://dx.doi.org/10.1016/j.saa.2021.120638 | DOI Listing |
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