AI Article Synopsis
- This study examines the impact of antibody-drug conjugates (ADCs) on refractive errors and keratopathy in cancer patients, specifically analyzing how certain corneal changes (microcyst-like epithelial changes or MECs) affect vision.
- Researchers conducted a retrospective analysis on 29 patients, focusing on changes in refractive error and keratometry during and after treatment with ADCs.
- Findings showed that peripheral MECs led to hyperopic shifts while central MECs caused myopic shifts, with many patients experiencing significant vision changes during treatment, although some returned to baseline after stopping the drug.
Article Abstract
Purpose: Antibody-drug conjugates (ADCs) are a class of cancer drug wherein some are associated with corneal abnormalities, but there is a dearth of published information on refractive shifts in patients receiving ADCs. Here, we evaluated the dynamics of refractive error and keratometry readings in patients with ADC-related keratopathy and microcyst-like epithelial changes (MECs).
Methods: This study is a retrospective case series including 58 eyes of 29 patients with ADC-related keratopathy from a single tertiary care cancer referral center (MSKCC). One eye (29 total) was randomly assigned for statistical analysis. In addition, a subset analysis of MEC location-refractive error correlation was performed on 20 eyes. Clinical records including slitlamp examination, indirect ophthalmoscopy, calculated spherical equivalence (SE), keratometry, and visual acuity were recorded at baseline, during, and off treatment.
Results: A subset analysis of MEC location-refractive error correlation of 20 eyes revealed the following: Peripheral MECs were significantly associated with hyperopic shifts (P value < 0.001) and paracentral/central associated with myopic shifts (P value < 0.001). In the full cohort and on drug, the greatest change in SE from baseline was myopic (68%, as high as -4.75 D) and hyperopic (32%, as much as +3.75 D). Eighty-nine percent had a change in vision from baseline while on drug, but at the 3-month follow-up off drug, SE and vision returned to baseline in 33% and 82% of eyes.
Conclusions: Peripheral MECs were significantly associated with hyperopic shifts, and paracentral/central MECs were associated with myopic shifts. While on drug, most eyes had a myopic refractive shift, which corresponded with corneal steepening.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106803 | PMC |
| http://dx.doi.org/10.1097/ICO.0000000000002934 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Viral diversity and host associations in microbial electrolysis cells.
ISME Commun
January 2024
Division of Water Environment Technology, Department of Architecture and Civil Engineering, Chalmers University of Technology, Sven Hultins gata 6, SE-412 96 Gothenburg, Sweden.
In microbial electrolysis cells (MECs), microbial communities catalyze conversions between dissolved organic compounds, electrical energy, and energy carriers such as hydrogen and methane. Bacteria and archaea, which catalyze reactions on the anode and cathode of MECs, interact with phages; however, phage communities have previously not been examined in MECs. In this study, we used metagenomic sequencing to study prokaryotes and phages in nine MECs.
View Article and Find Full Text PDFOccurrence, dispersal, and associated environmental risk assessment of pesticides and their transformation products in small water bodies of Northeastern France.
Environ Sci Pollut Res Int
December 2024
Université de Lorraine, INRAE, L2A, F-54500, Nancy, France.
The widespread use of pesticides, specifically plant protection products (PPPs), has led to their transformation products (TPs) being increasingly detected in various environmental compartments, notably surface waters. This study integrates field-detected TPs into an environmental risk assessment of lentic small water bodies (LSWBs). For this purpose, measured environmental concentrations (MECs) of PPPs and TPs in 12 LSWBs, influenced by tributaries under varying agricultural pressures, were collected.
View Article and Find Full Text PDFRNA-Seq Analysis of Pubertal Mammary Epithelial Cells Reveals Novel -3 Polyunsaturated Fatty Acid Transcriptomic Changes in the Mouse Model.
Nutrients
November 2024
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Article Synopsis
- Early nutrient exposure during puberty, particularly -3 polyunsaturated fatty acids (-3 PUFA), may lower breast cancer risk, but how they affect development at the cellular level is not well understood.
- A pilot study using RNA sequencing on mammary epithelial cells from mice showed significant changes in nine genes related to estrogen signaling, glycolysis, and immune responses due to lifelong exposure to -3 PUFA.
- This research emphasizes the need for further studies to explore how -3 PUFA influences mammary gland development at a cellular level, potentially impacting breast cancer risk.
[Sincipital meningoencephaloceles: Clinical and surgical considerations].
Ann Chir Plast Esthet
November 2024
Service de chirurgie maxillo-faciale et plastique de la face, hôpital Purpan, CHU de Toulouse, place du Dr-Baylac, TSA 40031, 31059 Toulouse cedex 9, France.
Sincipital meningoencephaloceles (MECs) are rare congenital malformations characterized by the herniation of brain or meningeal tissue through an opening in the anterior floor of the skull base. These malformations always affect the frontal bone, specifically the glabellar region and the naso-frontal angle. A collaboration between Médecins du Monde and the Children's Surgical Center in Phnom Penh has enabled the treatment of over four hundred cases over twenty years.
View Article and Find Full Text PDFThe clinical outcome, pathologic spectrum, and genomic landscape for 454 cases of salivary mucoepidermoid carcinoma.
NPJ Precis Oncol
October 2024
Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China.
Article Synopsis
- Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor of the salivary glands, primarily affecting females in their 40s and 50s, with the parotid gland being the most common site.
- The study examined 454 cases, highlighting that 414 patients were alive without relapse after an average of 62 months, while 40 experienced disease progression, often with the lungs as the main site of metastasis.
- Key findings indicate that specific histological gradings are linked to cancer recurrence and spread, with mutations in BAP1 and other genes correlating to aggressive forms of the disease, providing insights for targeted therapies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!