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Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD.
Liver Int
February 2025
Department of Epidemiology and Data Science, Amsterdam University Medical Centres, Amsterdam, The Netherlands.
Background And Aims: The performance of non-invasive liver tests (NITs) is known to vary across settings and subgroups. We systematically evaluated whether the performance of three NITs in detecting advanced fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) varies with age, sex, body mass index (BMI), type 2 diabetes mellitus (T2DM) status or liver enzymes.
Methods: Data from 586 adult LITMUS Metacohort participants with histologically characterised MASLD were included.
Arterial Stiffness and Subsequent Incidence of CKD and Kidney Function Decline in a Large Longitudinal Community Cohort: The Atherosclerosis in Communities (ARIC) Study.
Am J Kidney Dis
January 2025
Department of Epidemiology and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:
Rationale & Objective: Arterial stiffness is associated with prevalent chronic kidney disease (CKD). Whether arterial stiffness is prospectively associated with incident CKD is inconclusive.
Study Design: Longitudinal cohort study.
Structure and Functional Characteristics of Novel Polyurethane/Ferrite Nanocomposites with Antioxidant Properties and Improved Biocompatibility for Vascular Graft Development.
Polymers (Basel)
January 2025
Department of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Novel ferrite/polyurethane nanocomposites were synthesized using the in situ polymerization method after the addition of different spinel nanoferrite particles (copper, zinc, and copper-zinc) and examined as potential coatings for medical devices and implants in vascular tissue engineering. The influence of the nanoferrite type on the structure and functional characteristics of the polyurethane composites was investigated by FTIR, SWAXS, AFM, TGA, DSC, nanoindentation, swelling behavior, water contact angle, and water absorption measurements. Biocompatibility was evaluated by examining the cytotoxicity and adhesion of human endothelial cells and fibroblasts onto prepared composites and performing a protein adsorption test.
View Article and Find Full Text PDFJoint Analysis of Cardiovascular Control and Shear Wave Elastography to Determine Carotid Plaque Vulnerability.
J Clin Med
January 2025
Operative Unit of Vascular Surgery, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
: Carotid artery stenosis (CAS) is one of the main causes of stroke, and the vulnerability of plaque has been proved to be a determinant. A joint analysis of shear wave elastography, a radiofrequency echo-based wall tracking technique for arterial stiffness evaluation, and of autonomic and baroreflex function is proposed to noninvasively, preoperatively assess plaque vulnerability in asymptomatic CAS patients scheduled for carotid endarterectomy. : Elastographic markers of arterial stiffness were derived preoperatively in 78 CAS patients (age: 74.
View Article and Find Full Text PDFThe Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction.
Medicina (Kaunas)
December 2024
Centre of Clnical and Preclinical Research, MEDIPARK-University Research Park, Pavol Jozef Safarik University, Trieda SNP 1, 040 11 Kosice, Slovakia.
Metabolic syndrome (MS) represents several diseases encompassing a heterogeneous group of biochemical and physiological abnormalities characterized by structural and functional alterations in the myocardium, including the endothelium of the coronary arteries. MS also affects a substantial portion of the global population. Understanding the risk factors, the development and treatment associated with MS are of paramount importance for early identification, treatment and prevention.
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