AI Article Synopsis
- Anti-NMDA receptor encephalitis (anti-NMDARE) is an autoimmune disease that involves the immune system’s B cells and antibodies, and it may be influenced by the CD40/CD40L signaling pathway.
- In a study, researchers found that patients with anti-NMDARE had lower levels of CD40 and higher levels of CD40L in their serum compared to healthy individuals.
- Elevated levels of both CD40 and CD40L were observed during the acute phase of the disease, with a decrease during remission, indicating a potential role of the CD40/CD40L signaling pathway in the development of anti-NMDARE.
Article Abstract
Anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.
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| http://dx.doi.org/10.1016/j.jneuroim.2021.577762 | DOI Listing |
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