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| http://dx.doi.org/10.1186/s13054-021-03834-9 | DOI Listing |
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Prognostic role of midregional proadrenomedullin in predicting infection in pediatric cancer with febrile neutropenia.
Clin Exp Pediatr
January 2025
Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Background: Febrile neutropenia (FN) remains an important complication of cytotoxic chemotherapy for which an urgent and appropriate evaluation is imperative.
Purpose: To assess the diagnostic and prognostic roles of mid-regional pro-adrenomedullin (MR-ProADM) levels in predicting infection in patients with FN.
Methods: This comparative cross-sectional study included 137 patients with chemotherapy-induced FN.
Role of MR-proADM and Monocyte CD169 in Predicting In-Hospital and 60-Day Mortality in COVID-19 Patients.
Clin Pathol
December 2024
Department of Infectious Diseases, ASFO "Santa Maria degli Angeli" Hospital, Pordenone, Italy.
Objectives: Mid-regional pro-adrenomedullin (MR-proADM) and monocyte CD169 (CD169) are valuable prognostic indicators of severe COVID-19.
Methods: We assessed the predictive ability of a single measurement of MR-proADM and CD169 at emergency department (ED) admission to forecast in-hospital and 60-day mortality in adult COVID-19 patients. We analyzed clinical and laboratory data, with in-hospital mortality as the primary endpoint and 60-day mortality as the secondary endpoint.
Adrenomedullin as a New Prosperous Biomarker in Infections: Current and Future Perspectives.
J Clin Med
October 2024
Department of Infectious Diseases and Neuroinfections, Medical Uniwersity of Bialystok, 15-540 Bialystok, Poland.
Adrenomedullin has emerged as a promising biomarker in the field of viral diseases. Numerous studies have demonstrated its potential in assessing disease severity, predicting clinical outcomes, and monitoring treatment response. Adrenomedullin (AM) is a multifaceted peptide implicated in vasodilation, hormone secretion, antimicrobial defense, cellular growth, angiogenesis, and, importantly, chronic pain.
View Article and Find Full Text PDFEndothelial Biomarkers Are Superior to Classic Inflammatory Biomarkers in Community-Acquired Pneumonia.
Biomedicines
October 2024
Pneumology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.
Article Synopsis
- Complications from community-acquired pneumonia (CAP), such as cardiovascular events and mortality, can arise both during the illness and afterward; this study explores the role of specific biomarkers related to endothelial damage compared to traditional inflammation markers.
- The research analyzed data from 515 patients, measuring various biomarkers at different time intervals (day 1, day 5, and day 30) to determine their relationship with ICU admission, cardiovascular events, and mortality.
- Findings indicated that endothelial damage biomarkers (CT-proET-1 and MR-proADM) were more strongly associated with negative outcomes than inflammation markers (CRP and PCT), with MR-proADM being the most effective at predicting complications in both the short and long term.
A Focus on the Pathophysiology of Adrenomedullin Expression: Endothelitis and Organ Damage in Severe Viral and Bacterial Infections.
Cells
May 2024
Unit of Laboratory, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Adrenomedullin (ADM) is a peptide hormone produced primarily in the adrenal glands, playing a crucial role in various physiological processes. As well as improving vascular integrity and decreasing vascular permeability, ADM acts as a vasodilator, positive inotrope, diuretic, natriuretic and bronchodilator, antagonizing angiotensin II by inhibiting aldosterone secretion. ADM also has antihypertrophic, anti-apoptotic, antifibrotic, antioxidant, angiogenic and immunoregulatory effects and antimicrobial properties.
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