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Background: While the bioavailability of cocoa polyphenols, particularly of the monomer (-)-epicatechin, has been investigated after a single-dose intake, the effect of sustained cocoa consumption on the metabolic profile of the structurally related (-)-epicatechin metabolites (SREMs) has not been investigated.
Methods: A randomized, controlled crossover clinical trial in healthy young adults (18-40 year) was conducted to evaluate SREMs after consumption of a single-dose and after daily consumption of 1.3 g of polyphenol-rich cocoa powder for 28 days. The circulating SREMs were measured by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).
Results: Twenty subjects (eleven males and nine females) were enrolled. The SREMs concentrations increased to 1741 ± 337 nM after a single-dose and to 1445 ± 270 nM after sustained supplementation. Sulfate conjugates showed higher levels in females ( < 0.05). The epicatechin-3'-glucuronide (E3'G) and epicatechin-3'-sulfate (E3'S) were the most abundant metabolites in all subjects. A high intra-individual correlation (r = 0.72, < 0.001) between SREMs concentrations after single-dose and sustained supplementation was observed. The antioxidant capacity of plasma did not change in response to the intervention and was not correlated with any of the SREMs.
Conclusion: The individual SREMs profile and concentrations after a 28-day supplementation are comparable to those after a single dose.
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http://dx.doi.org/10.3390/nu13113829 | DOI Listing |
Future Microbiol
December 2024
Department of Pharmacy, Pharmaceutical Biology Laboratory, Universidade Estadual de Maringá, Maringá, Brazil.
Objectives: To evaluate the antifungal activity of extracts and compounds from against clinically relevant species, notably , and investigate possible mechanisms of action using electron microscopy and techniques.
Methods: Extracts and fractions of were obtained through turboextraction and partitioning, while the isolated compounds were previously purified. The ethyl acetate fraction (EAF) was characterized by HPLC.
Food Chem
December 2024
Antioxidant Polyphenols Team, Department of Food Engineering, Sichuan University, Chengdu 610065, PR China; The Key Laboratory of Food Science and Technology of Sichuan Province of Education, Sichuan University, Chengdu 610065, PR China. Electronic address:
Regulation of catechins with different structure characteristics on the physicochemical properties of casein were investigated, and the structure-activity relationship was further explored. All testing catechins effectively modulated the physicochemical properties of casein, and esterified catechins showed the stronger binding affinity to casein than non-esterified catechins. Catechins significantly altered the secondary and tertiary structures of casein.
View Article and Find Full Text PDFUltrason Sonochem
December 2024
College of Food Science and Technology/National R&D Branch Center for Conventional Freshwater Fish Processing (Wuhan), Huazhong Agricultural University, Wuhan 430070, PR. China. Electronic address:
This study was designed to obtain the maximum extraction yield of peanut shell (PS) polyphenols using a novel carbon dioxide nanobubbles (CO-NBs) assisted ultrasonic extraction method. CO-NBs were generated in distilled water with a self-developed high-pressure nano-jet homogenization method and characterized by size, zeta potential and transmission electron microscopy (TEM). The obtained nanobubble's mean size and zeta potential were 229.
View Article and Find Full Text PDFMolecules
November 2024
Traditional and Modern Medicine Research and Development Directorate, Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
is widely used in Ethiopia for treating various human ailments, yet its pharmacological properties and chemical composition remain largely unexplored. The chromatographic separation of roots extract afforded five compounds, namely tremulacin (), cochinchiside A (), 5-methoxydurmillone (), catechin-7--α-L-rhamnopyranoside (), and stigmasterol (), confirmed via IR, NMR, and MS spectral data. This is the first report of these compounds from this plant, except for compounds and .
View Article and Find Full Text PDFACS Omega
December 2024
Department of Bioinformatics, Bharathidasan University, Tiruchirappalli, Tamilnadu 620024, India.
Atherosclerosis (ASC) is characterized by foam cell-mediated plaque formation, vascular endothelial inflammation, and lipidosis and is the rudimentary cause of cardiovascular diseases. This is the pre-eminent global factor of mortality. This etiological paradigm is significantly influenced by several proteins, where 23 pivotal proteins involved in ASC were meticulously gleaned on the basis of literature studies.
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