Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619259 | PMC |
| http://dx.doi.org/10.3390/nano11112971 | DOI Listing |
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Vertical Orientation Probability Matters for Enhancing Nanoparticle-Macrophage Interaction and Efficient Phagocytosis.
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May 2022
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.
The geometry of nanoparticles has a profound effect on their interactions with macrophages. For an elongated geometry, the well-known curvature-dependent phagocytosis mechanism is still under debate, presumably because another important parameter, the probability of orientation, is overlooked. To verify this hypothesis, it is demonstrated that increasing the probability of the preferred vertical orientation is an efficient strategy to significantly enhance macrophage phagocytosis and uptake.
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Nanoparticles (NPs) offer unique properties for biomedical applications, leading to new nanomedicines [...
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