Materials based on calcium carbonate (CaCO) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: orubicin (). We also showed a prolonged pH-dependent release of from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO-and--based composite (CaNP-) in in vitro models.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625994 | PMC |
| http://dx.doi.org/10.3390/nano11112794 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Could CGRP mAbs for migraine trigger rheumatoid arthritis? Insights from a case report.
ARP Rheumatol
January 2024
ULS Gaia e Espinho.
Background: Case reports suggest that calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) may trigger inflammatory flares in patients with autoimmune diseases.
Case Description: A 56-year-old woman with a history of severe migraines, experienced improvement in migraine frequency and intensity after starting fremanezumab 225 mg monthly. However, three months into treatment, she developed symmetric inflammatory polyarthralgias.
Response Surface D-Optimal Design for Optimizing Fortimicins Production by Micromonospora olivasterospora and New Synergistic Fortimicin-A-Antibiotic Combinations.
Curr Microbiol
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
Fortimicins (FTMs) are fortamine-containing aminoglycoside antibiotics (AGAs) produced by M. olivasterospora DSM 43868 with excellent bactericidal activities against a wide range of Enterobacteriaceae and synergistic activity against multidrug-resistant (MDR) pathogens. Fortimicin-A (FTM-A), the most active member of FTMs, has the lowest susceptibility to inactivation by the aminoglycoside modifying enzymes (AMEs).
View Article and Find Full Text PDFCalcium Carbonate from Anadara granosa Shells Stimulates FGF2, TGF-β1, and Collagen Type 1 Expression in Rat Dental Pulp.
Eur J Dent
December 2024
Postgraduate Program of Conservative Dentistry Specialist, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Objectives: Calcium carbonate (CaCO), a major inorganic component in bones and teeth, offers potential protection against demineralization. This study investigates the effect of CaCO from shells on the expression of fibroblast growth factor 2 (FGF2), transforming growth factor-β1 (TGF-β1), and collagen type 1 in the rat dental pulp.
Materials And Methods: The first maxillary molars of were perforated and subsequently pulp capped with CaCO extracted from shells.
Effect of stearic acid and sodium stearate on hydrophobicity of nano calcium carbonate and mechanism of water vapor adsorption.
Sci Rep
January 2025
Guangxi Academy of Sciences, Nanning, 530000, People's Republic of China.
It is essential to understand the modification mechanism of hydrophobicity nano-CaCO to their potential application in different fields of chemistry. However, the water absorption of hydrophobicity nano-CaCO is seldom studied. In this study, Raman, BET and TGA experiments were performed on nano-CaCO samples to obtain surfactants contents and microstructure characteristics.
View Article and Find Full Text PDFThe hidden role of heterotrophic bacteria in early carbonate diagenesis.
Sci Rep
January 2025
Ali I. Al-Naimi Petroleum Engineering Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Microbial impacts on early carbonate diagenesis, particularly the formation of Mg-carbonates at low temperatures, have long eluded scientists. Our breakthrough laboratory experiments with two species of halophilic aerobic bacteria and marine carbonate grains reveal that these bacteria created a distinctive protodolomite (disordered dolomite) rim around the grains. Scanning Electron Microscopy (SEM) and X-ray Diffraction (XRD) confirmed the protodolomite formation, while solid-state nuclear magnetic resonance (NMR) revealed bacterial interactions with carboxylated organic matter, such as extracellular polymeric substances (EPS).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!