group (MFG) members are able to cause clinical mycobacteriosis in fish and other animals including humans. , , , , , , , , and were isolated from fish with mycobacteriosis. In other animals only three MFG species have been isolated: from camels' milk, from cutaneous infections often described as "farcy", and from different domestic and wild mammals' species. Out of 17, only 3 MFG species (, and ) have never been reported in humans. A total of eight MFG members (, , , subsp. , , , , and ) have been isolated from both pulmonary and extrathoracic locations. In extrathoracic tissues five MFG species (, , , , and ) have been diagnosed and only one MFG member ( subsp. ) has been isolated from pulmonary infection.
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http://dx.doi.org/10.3390/microorganisms9112345 | DOI Listing |
J Virol
November 2024
Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
Influenza A viruses (IAVs) from the H5N1 2.3.4.
View Article and Find Full Text PDFPharmaceutics
August 2024
Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Micafungin (MFG) is a widely used echinocandin antifungal agent for treating invasive candidiasis, particularly in critically ill patients. However, its pharmacokinetics can be highly variable in this population. This systematic review aims to summarize population pharmacokinetic models and provide recommendations for its use in intensive care unit (ICU) patients.
View Article and Find Full Text PDFJ Biomed Mater Res A
September 2024
Department of Zoology, Uluberia College, University of Calcutta, Howrah, India.
In the study, we have shown the efficacy of an indigenously developed redox balancing chitosan gel with impregnated citrate capped MnO nanoparticles (nanogel). Application of the nanogel on a wound of preclinical mice model shows role of various signaling molecules and growth factors, and involvement of reactive oxygen species (ROS) at every stage, namely hemostasis, inflammation, and proliferation leading to complete maturation for the scarless wound healing. While in vitro characterization of nanogel using SEM, EDAX, and optical spectroscopy reveals pH regulated redox buffering capacity, in vivo preclinical studies on Swiss albino involving IL-12, IFN-γ, and α-SMA signaling molecules and detailed histopathological investigation and angiogenesis on every stage elucidate role of redox buffering for the complete wound healing process.
View Article and Find Full Text PDFJ Virol
April 2024
Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Influenza A viruses (IAVs) can overcome species barriers by adaptation of the receptor-binding site of the hemagglutinin (HA). To initiate infection, HAs bind to glycan receptors with terminal sialic acids, which are either -acetylneuraminic acid (NeuAc) or -glycolylneuraminic acid (NeuGc); the latter is mainly found in horses and pigs but not in birds and humans. We investigated the influence of previously identified equine NeuGc-adapting mutations (S128T, I130V, A135E, T189A, and K193R) in avian H7 IAVs and .
View Article and Find Full Text PDFJ Dairy Res
November 2023
Department of Chemistry, Faculty of Science, Kyushu University, Fukuoka, Japan.
The milk fat globule membrane (MFGM) is formed by complex cell biological processes in the lactating mammary epithelial cell which result in the release of the milk fat globule (MFG) into the secretory alveolus. The MFG is bounded by a continuous unit membrane (UM), separated from the MFG lipid by a thin layer of cytoplasm. This unique apocrine secretion process has been shown in all of the mammary species so far investigated.
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