AI Article Synopsis
- - Dengue viruses are a major global public health concern, with transmission risks expanding beyond tropical regions due to the increasing range of their primary mosquito vector.
- - In Florida, dengue fever outbreaks have been rising since 2009, but there is limited knowledge about how different regional mosquito populations transmit these viruses.
- - Research found that mosquitoes in south Florida, especially those exposed to low passage dengue viruses, showed higher transmission potential, indicating that specific mosquito-virus combinations significantly impact the risk of dengue transmission.
Article Abstract
Dengue viruses (DENVs) cause the greatest public health burden globally among the arthropod-borne viruses. DENV transmission risk has also expanded from tropical to subtropical regions due to the increasing range of its principal mosquito vector, . Focal outbreaks of dengue fever (dengue) in the state of Florida (FL) in the USA have increased since 2009. However, little is known about the competence of populations across different regions of FL to transmit DENVs. To understand the effects of DENV genotype and serotype variations on vector susceptibility and transmission potential in FL, we orally infected a colony of (Orlando/ORL) with low passage or laboratory DENV-1 through -4. Low passage DENVs were more infectious to and had higher transmission potential by ORL mosquitoes. We used these same DENVs to examine natural populations to determine whether spatial distributions correlated with differential vector competence. Vector competence across all DENV serotypes was greater for mosquitoes from areas with the highest dengue incidence in south FL compared to north FL. Vector competence for low passage DENVs was significantly higher, revealing that transmission risk is influenced by virus/vector combinations. These data support a targeted mosquito-plus-pathogen screening approach to more accurately estimate DENV transmission risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622774 | PMC |
| http://dx.doi.org/10.3390/v13112232 | DOI Listing |
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