AI Article Synopsis
- This study explores the synthesis of gold nanoparticles (PtubAuNPs) using flower filtered extract, which serves both as a reducing and stabilizing agent.
- PtubAuNPs were thoroughly characterized and found to exhibit strong antibacterial properties against various pathogens, tested using the agar well diffusion method.
- The nanoparticles also demonstrated cytotoxic effects in MCF 7 cancer cells, showing dose-dependent toxicity and inducing apoptosis at a concentration of 100 µg/mL.
Article Abstract
The developments of green-based metallic nanoparticles (gold) are gaining tremendous interest, having potential applications in health care and diagnosis. Therefore, in the present study, flower filtered extract was used as a reducing and stabilizing agent to synthesize gold nanoparticles (PtubAuNPs). The PtubAuNPs were extensively characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and X-ray diffraction. The antibacterial activity of PtubAuNPs was determined by the agar well diffusion method; the PtubAuNPs performed extreme antagonistic activity against the tested pathogens. Furthermore, the cytotoxicity of the PtubAuNPs was evaluated in MCF 7 cells by MTT assay. The PtubAuNPs induced toxicity in MCF 7 cells with the least concentration of 100 µg/mL in a dose-dependent method by inducing apoptosis. Overall, the study manifested that PtubAuNPs are a potent nanomaterial that can be employed as an antimicrobial and anticancer agent.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624474 | PMC |
| http://dx.doi.org/10.3390/plants10112370 | DOI Listing |
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