AI Article Synopsis
- The study investigates the relationship between leukocyte telomere length (LTL) and treatment-resistant depression (TRD), including patients with major depressive disorder and bipolar disorder.
- Results showed that LTL was shorter in TRD patients compared to non-psychiatric controls, indicating a link to accelerated cellular aging in severe psychiatric disorders.
- However, shorter LTL did not correlate with better response to electroconvulsive therapy (ECT), suggesting that LTL may not be a useful predictive biomarker for treatment outcomes.
Article Abstract
Psychiatric disorders seem to be characterized by premature cell senescence. However, controversial results have also been reported. In addition, the relationship between accelerated aging and treatment-resistance has scarcely been investigated. In the current study, we measured leukocyte telomere length (LTL) in 148 patients with treatment-resistant depression (TRD, 125 with major depressive disorder, MDD, and 23 with bipolar disorder, BD) treated with electroconvulsive therapy (ECT) and analyzed whether LTL was associated with different response profiles. We also compared LTL between patients with TRD and 335 non-psychiatric controls. For 107 patients for which genome-wide association data were available, we evaluated whether a significant overlap among genetic variants or genes associated with LTL and with response to ECT could be observed. LTL was negatively correlated with age (Spearman's correlation coefficient = -0.25, < 0.0001) and significantly shorter in patients with treatment-resistant MDD (Quade's F = 35.18, < 0.0001) or BD (Quade's F = 20.84, < 0.0001) compared to controls. Conversely, baseline LTL was not associated with response to ECT or remission. We did not detect any significant overlap between genetic variants or genes associated with LTL and response to ECT. Our results support previous findings suggesting premature cell senescence in patients with severe psychiatric disorders and suggest that LTL could not be a predictive biomarker of response to ECT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622097 | PMC |
| http://dx.doi.org/10.3390/jpm11111100 | DOI Listing |
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