AI Article Synopsis
Article Abstract
The aims of this study were to characterize the antifungal activity of amphotericin B against in a static in vitro system and to evaluate different dosing schedules and MIC scenarios by means of semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation. A two-compartment model consisting of a drug-susceptible and a drug-resistant subpopulation successfully characterized the time-kill data and a modified E sigmoidal model best described the effect of the drug. The model incorporated growth rate constants for both subpopulations, a death rate constant and a transfer constant between both compartments. Additionally, the model included a parameter to account for the delay in growth in the absence or presence of the drug. Amphotericin B displayed a concentration-dependent fungicidal activity. The developed PK/PD model was able to characterize properly the antifungal activity of amphotericin B against . Finally, simulation analysis revealed that none of the simulated standard dosing scenarios of 0.6, 1 and 1.5 mg/kg/day over a week treatment showed successful activity against infection. Simulations also pointed out that an MIC of 1 mg/L would be linked to treatment failure for invasive infections and therefore, the resistance rate to amphotericin B may be higher than previously reported.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8624019 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics13111767 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mathematical and computational modeling for organic and insect frass fertilizer production: A systematic review.
PLoS One
January 2025
Data Management, Modelling and Geo-Information Unit, International Centre of Insect Physiology and Ecology, Kenya.
Organic fertilizers have been identified as a sustainable agricultural practice that can enhance productivity and reduce environmental impact. Recently, the European Union defined and accepted insect frass as an innovative and emerging organic fertilizer. In the wider domain of organic fertilizers, mathematical and computational models have been developed to optimize their production and application conditions.
View Article and Find Full Text PDFThe global convergence of some self-scaling conjugate gradient methods for monotone nonlinear equations with application to 3DOF arm robot model.
PLoS One
January 2025
Faculty of Education and Arts, Sohar University, Sohar, Oman.
Conjugate Gradient (CG) methods are widely used for solving large-scale nonlinear systems of equations arising in various real-life applications due to their efficiency in employing vector operations. However, the global convergence analysis of CG methods remains a significant challenge. In response, this study proposes scaled versions of CG parameters based on the renowned Barzilai-Borwein approach for solving convex-constrained monotone nonlinear equations.
View Article and Find Full Text PDFBayesian Spatial Relative Survival Model to Estimate the Loss in Life Expectancy and Crude Probability of Death for Cancer Patients.
Stat Med
February 2025
School of Mathematical Science, Queensland University of Technology, Brisbane, Australia.
To date, there have not been any population-based cancer studies quantifying geographical patterns of the loss in life expectancy (LLE) and crude probability of death due to cancer ( ). These absolute measures of survival are complementary to the more typically used relative measures of excess mortality and relative survival, and, together, they provide a fuller understanding of geographical disparities in survival outcomes for cancer patients. We propose using a spatially flexible parametric relative survival model in the Bayesian framework, which allows for the inclusion of spatial effects in hazard-level model components.
View Article and Find Full Text PDFComputational simulation of cranial soft tissue expansion on the cranium during early postnatal growth in humans.
J Anat
January 2025
Department of Musculoskeletal & Ageing Science, Institute of Life Course & Medical Sciences (ILCaMS) and Human Anatomy Resource Centre (HARC), Education Directorate, University of Liverpool, Liverpool, UK.
The importance of interactions between neighbouring rapidly growing tissues of the head during development is recognised, yet this competition for space remains incompletely understood. The developing structures likely interact through a variety of mechanisms, including directly genetically programmed growth, and are mediated via physiological signalling that can be triggered by structural interactions. In this study, we aimed to investigate a different but related potential mechanism, that of simple mechanical plastic deformation of neighbouring structures of the head in response to soft tissue expansion during human postnatal ontogeny.
View Article and Find Full Text PDFExploring Adhesive Performance in Horseshoe Bonding Through Advanced Mechanical and Numerical Analysis.
Biomimetics (Basel)
December 2024
Department of Mechanical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.
Despite technological advancements in various industries, the equine sector still relies on old methods like horseshoeing. Although traditional, the industry is dynamic and well-funded. Therefore, there is a need to modernize these methods with more reliable and less invasive solutions for attaching horseshoes to horse hooves.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!