AI Article Synopsis
- Protein kinase C (PKC) is a family of enzymes divided into three subfamilies: classic (cPKCs), novel (nPKCs), and atypical (aPKCs), based on their structure and activation.
- PKC activators and inhibitors are important for studying intracellular signaling and are explored for treating diseases related to PKC, including cancers and neurological disorders.
- Clinical trials using PKC inhibitors for cancer treatment have often shown limited success, highlighting challenges in developing effective cancer therapies targeting PKC alone.
Article Abstract
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or non-classic PKC isozymes (nPKCs; δ, ε, η, and θ), and atypical PKC isozymes (aPKCs; ζ, ι, and λ). PKC inhibitors and activators are used to understand PKC-mediated intracellular signaling pathways and for the diagnosis and treatment of various PKC-associated diseases, such as cancers, neurological diseases, cardiovascular diseases, and infections. Many clinical trials of PKC inhibitors in cancers showed no significant clinical benefits, meaning that there is a limitation to design a cancer therapeutic strategy targeting PKC alone. This review will focus on the activators and inhibitors of PKC and their applications in clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621927 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics13111748 | DOI Listing |
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