A known polyoxygenated briarane, briaexcavatolide P (), was isolated from a Formosan octocoral . Moreover, the same species , collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B () and C () as well as a known analogue, briarenol R (). The structures of - were established using spectroscopic methods. In addition, briarane demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.
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| http://dx.doi.org/10.3390/molecules26226861 | DOI Listing |
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