AI Article Synopsis
- Smart polymer-based micro/nanoassemblies are innovative carriers for transporting and delivering various cargo while preserving their activity en route to target sites.
- These carriers utilize phototriggering mechanisms, allowing precise control over cargo release and enhancing therapeutic effects by using light as an external stimulus.
- The review highlights advancements in different types of polymeric carriers and their applications in biomedical and environmental fields, while also addressing the challenges and potential of light-stimulated micromotors in drug delivery systems.
Article Abstract
Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo. Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (PC) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target. PCs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect. Micromotors based on PCs offer an accelerated cargo-medium interaction for biomedical, environmental, and many other applications. This review collects the recent achievements in PC development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (UV) and near-infrared (NIR) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy. We emphasize the challenges of positioning PCs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8621231 | PMC |
| http://dx.doi.org/10.3390/polym13223920 | DOI Listing |
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