AI Article Synopsis
- The study explores the oral microbiome's role in dental diseases and aims to reduce bacterial presence using innovative chitosan-based films.
- Various compositions were created and analyzed for their chemical structures and physical properties using advanced techniques like FTIR, SEM, and XRD.
- While only the glutaraldehyde crosslinked chitosan film showed antimicrobial activity against certain bacteria, all films displayed activity against others, suggesting potential use in medical and food applications.
Article Abstract
The role of the oral microbiome and its effect on dental diseases is gaining interest. Therefore, it has been sought to decrease the bacterial load to fight oral cavity diseases. In this study, composite materials based on chitosan, chitosan crosslinked with glutaraldehyde, chitosan with zinc oxide particles, and chitosan with copper nanoparticles were prepared in the form of thin films, to evaluate a new alternative with a more significant impact on the oral cavity bacteria. The chemical structures and physical properties of the films were characterized using by Fourier transform infrared spectroscopy (FTIR,) Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), elemental analysis (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and contact angle measurements. Subsequently, the antimicrobial activity of each material was evaluated by agar diffusion tests. No differences were found in the hydrophilicity of the films with the incorporation of ZnO or copper particles. Antimicrobial activity was found against in the chitosan film crosslinked with glutaraldehyde, but not in the other compositions. In contrast antimicrobial activity against was found in all films. Based on the data of present investigation, chitosan composite films could be an option for the control of microorganisms with potential applications in various fields, such as medical and food industry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619498 | PMC |
| http://dx.doi.org/10.3390/polym13223861 | DOI Listing |
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