Alpha-Synuclein and Cognitive Decline in Parkinson Disease.

Life (Basel)

Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei City 100, Taiwan.

Published: November 2021

Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625417PMC
http://dx.doi.org/10.3390/life11111239DOI Listing

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