AI Article Synopsis
- L-lysine α-oxidase (LO) is an enzyme that breaks down L-lysine, producing hydrogen peroxide (HO), ammonia, and α-keto-ε-aminocaproate, which may help in cancer treatment.
- Multiple studies demonstrate LO's effectiveness against tumors, showcasing its cytotoxic, antitumor, and antimetastatic properties, with promising results in specific human colon cancer models.
- The review highlights LO's unique dual mechanism of action and its potential as a therapeutic agent in colon cancer, emphasizing recent findings on its biological effects.
Article Abstract
L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of HO, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of HO, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618108 | PMC |
| http://dx.doi.org/10.3390/ph14111070 | DOI Listing |
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