AI Article Synopsis
- * The patient was diagnosed with Serratia liquefaciens pneumonia and acute respiratory failure, but his health worsened despite receiving various treatments.
- * After confirming TB infection using QuantiFERON-TB Gold Plus, antituberculosis therapy was started, leading to significant health improvements and the patient was discharged with ongoing medication recommendations.
Article Abstract
Tuberculosis (TB) is an important opportunistic infection in HIV-positive people. We are reporting a case of a 31-year-old HIV-infected patient who was hospitalized in July 2021 for dyspnea, cough with mucopurulent sputum and asthenia. He was confirmed to have Serratia liquefaciens pneumonia and acute respiratory failure. The evolution was unfavorable despite the antibiotic, pathogenic and symptomatic treatment. Because the patient had severe immunosuppression (CD4 count = 37 cell/mm), we used QuantiFERON-TB Gold Plus for the detection of the Mycobacterium tuberculosis infection. The antituberculosis therapy was initiated, which resulted in a significant improvement of the general condition and the patient was discharged with the recommendation to continue antiretroviral therapy, antituberculosis treatment and Trimethoprim/Sulfamethoxazole-single tablet daily for the prophylaxis of Pneumocystis pneumonia.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620343 | PMC |
| http://dx.doi.org/10.3390/pathogens10111523 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi.
J Clin Microbiol
December 2024
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Unlabelled: Urgent improvements in the diagnosis and management of infection are required to reach End TB goals. Conventional interferon-gamma release assays (IGRAs), such as QuantiFERON-TB Gold Plus (QFT-Plus), require substantial laboratory infrastructure and large blood volumes, limiting use in high-burden settings. The QIAreach QuantiFERON-TB (QIAreach QFT) was developed to overcome these challenges but has not previously been evaluated in field conditions in a low-income, high-burden country, or at scale in children.
View Article and Find Full Text PDFThe new gamma interferon (IFN-γ) algorithm for tuberculosis diagnosis in cynomolgus macaques.
PLoS One
December 2024
Office of Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tuberculosis (TB) is the first infectious disease to be screened-out from specified pathogen-free cynomolgus macaques (Macaca fascicularis; Mf) using in human pharmaceutical testing. Being in either latent or active stage after exposure to the Mycobacterium tuberculosis complex (MTBC), the monkey gamma-interferon release assay (mIGRA) was previously introduced for early TB detection. However, a notable incidence of indeterminate results was observed.
View Article and Find Full Text PDFPerformance of the T-SPOT.TB test in patients with indeterminate QuantiFERON-TB Gold Plus results: proposal for an algorithm for the diagnosis of Latent Tuberculosis Infection.
Infez Med
December 2024
Clinical Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Latent Tuberculosis Infection (LTBI) is a state of persistent immune response to complex antigens without clinical, radiological and microbiological signs of active disease. Effective diagnosis and preventive treatment of LTBI are crucial for tuberculosis (TB) control, especially in high-risk groups. Currently, two main tests are used for LTBI diagnosis: the Tuberculin Skin Test (TST) and the Interferon-Gamma Release Assays (IGRA), including the QuantiFERON-TB Gold Plus (QFT-Plus) and the T-SPOT.
View Article and Find Full Text PDFSeroconversion of QuantiFERON-TB Gold Test due to Mycobacterium marinum Infection in a Patient with Psoriasis Treated with Adalimumab.
Acta Derm Venereol
November 2024
Department of Dermatology, Skåne University Hospital, Malmö, Sweden; Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden.
Retrospective data analysis on the prevalence and demographic risk factors for latent tuberculosis infection (LTBI) cases from a private laboratory in Malaysia.
Trop Biomed
September 2024
Premier Integrated Labs, Pantai Hospital Ampang, Jalan Perubatan 1, 55100, Pandan Indah, Kuala Lumpur, Malaysia.
Tuberculosis (TB) is a critical disease that predominantly affects the lungs. This disease remains a global health threat. Currently, the incidence of TB is estimated to be 92 cases in every 100 000 population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!