Background: The incidence of small intestinal (SI) and pancreatic neuroendocrine tumors (siNETs and pNETs) seems to have increased. The increased frequency of incidental findings might be a possible explanation. The study aimed to examine (1) changes in incidence and the stage at diagnosis (2010-2011 vs. 2019-2020), (2) changes in the initial indication for diagnostic workup and 3) the differences in stage between incidentally discovered vs. symptomatic disease during the entire study period.
Methods: We performed a retrospective study, that includes consecutive siNET and pNET patients referred to the Copenhagen ENETS center of excellence in 2010-2011 and 2019-2020.
Results: The annual incidence of siNET per 100,000 increased from 1.39 to 1.84, ( = 0.05). There was no change in the stage at diagnosis, and in both periods approximately 30% of patients were incidentally diagnosed ( = 0.62). Dissemination was found in 72/121 (60%) of symptomatic vs. 22/50 (44%) of incidentally discovered SI tumors in the entire cohort, ( = 0.06). The annual incidence of pNET increased from 0.42 to 1.39 per 100,000, ( < 0.001). The proportion of patients with disseminated disease decreased from 8/21 (38%) to 12/75 (16%), ( = 0.02) and the number of incidental findings increased from 4/21 (19%) to 43/75 (57%), ( = 0.002). More symptomatic patients had disseminated disease compared to patients with incidentally discovered tumors (15/49 (31%) vs. 5/47 (11%), ( = 0.01)).
Conclusion: The incidence of siNET and pNETs increased over the past decade. For siNETs, the stage of disease and the distribution of symptomatic vs. incidentally discovered tumors were unchanged between the two periods. Patients with pNETs presented with more local and incidentally discovered tumors in the latter period. Patients with incidentally discovered siNETs had disseminated disease in 44% of the overall cases. The vast majority of incidentally found pNETs were localized.
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http://dx.doi.org/10.3390/diagnostics11112030 | DOI Listing |
Cureus
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Department of Medicine, Division of Endocrinology and Metabolism, King Abdulaziz Medical City, Riyadh, SAU.
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"Situs inversus with levocardia" refers to the mirror-image lateral orientation of the abdominal organs with a normally oriented, left-sided heart. This anatomical anomaly arises from abnormalities in the biochemical signaling systems mediating embryological development. We present a case of situs inversus with levocardia incidentally discovered in a healthy 24-year-old male during workup following a motor vehicle collision.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
Department of Radiology, Mie University, 2-174 Edobashi, Tsu, 514-8507 Mie, Japan.
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Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH.
Acta Radiol Open
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Radiology Department, Mohammed VI University Hospital, Tangier, Morroco.
Cardiac metastases are the most frequent cardiac tumors. They can cause dysrhythmia, myocardial dysfunction, pericardial effusion, and heart failure. In decreasing order, the major primary malignancies associated with cardiac metastases are pleural mesothelioma, lung adenocarcinoma, undifferentiated carcinomas, lung squamous cell carcinoma, and breast carcinoma.
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