AI Article Synopsis

  • Recent research indicates that many repetitive genome sequences are expressed as RNA, but their functions remain unclear.
  • Some known transcribed repeats include mammalian Alu sequences and certain satellite DNAs, yet little is studied about interspersed satellites across various species.
  • Our study reveals that abundant DNA satellites in bacteria and nematodes are widely transcribed, adding a new category of non-coding RNAs and highlighting the need for further exploration into their role in gene expression.

Article Abstract

It has been shown in recent years that many repeated sequences in the genome are expressed as RNA transcripts, although the role of such RNAs is poorly understood. Some isolated and tandem repeats (satellites) have been found to be transcribed, such as mammalian Alu sequences and telomeric/centromeric satellites in different species. However, there is no detailed study on the eventual transcription of the interspersed satellites found in many species. Therefore, we decided to study for the first time the transcription of the abundant DNA satellites in the bacterium and in the nematode . We have updated the data for satellites using the latest version of the genome. We analyzed the transcription of satellites in both species in available RNA-seq results and found that they are widely transcribed. Our demonstration that satellite RNAs are transcribed adds a new family of non-coding RNAs. This is a field that requires further investigation and will provide a deeper understanding of gene expression and control.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625621PMC
http://dx.doi.org/10.3390/genes12111651DOI Listing

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