A family of heterogeneous mean-field systems with jumps is analyzed. These systems are constructed as a Gibbs measure on block graphs. When the total number of particles goes to infinity, the law of large numbers is shown to hold in a multi-class context, resulting in the weak convergence of the empirical vector towards the solution of a McKean-Vlasov system of equations. We then investigate the local stability of the limiting McKean-Vlasov system through the construction of a local Lyapunov function. We first compute the limit of adequately scaled relative entropy functions associated with the explicit stationary distribution of the -particles system. Using a Laplace principle for empirical vectors, we show that the limit takes an explicit form. Then we demonstrate that this limit satisfies a descent property, which, combined with some mild assumptions shows that it is indeed a local Lyapunov function.
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http://dx.doi.org/10.3390/e23111407 | DOI Listing |
J Environ Manage
January 2025
Tetra Tech, Inc., P.O. Box 14409, Research Triangle Park, NC, 27709, United States. Electronic address:
Due to the recent improved availability of global and regional climate change (CC) models and associated data, the projected impact of CC on urban stormwater management is well documented. However, most studies are based on simplified design storm analysis and unit-area runoff models; evaluations of the long-term, continuous hydrologic response of extensive stormwater control measures (SCM) implementation under future CC scenarios are limited. Moreover, channel stability in response to CC is seldom evaluated due to the input data required to develop a long-term, continuous sediment transport model.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Emory University, Chemistry, 1515 Dickey Dr., 30322, Atlanta, UNITED STATES OF AMERICA.
Genetically encoded tension sensors (GETSs) allow for quantifying forces experienced by intracellular proteins involved in mechanotransduction. The vast majority of GETSs are comprised of a FRET pair flanking an elastic "spring-like" domain that gradually extends in response to force. Because of ensemble averaging, the FRET signal generated by such analog sensors conceals forces that deviate from the average, and hence it is unknown if a subset of proteins experience greater magnitudes of force.
View Article and Find Full Text PDFPLoS Genet
January 2025
Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, India.
During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability. Here, we show that shugoshin (Sgo1), a conserved tension-sensing protein, ensures the maintenance of SAC signals in response to unattached kinetochores during mitosis in a basidiomycete budding yeast Cryptococcus neoformans.
View Article and Find Full Text PDFBiological memory networks are thought to store information by experience-dependent changes in the synaptic connectivity between assemblies of neurons. Recent models suggest that these assemblies contain both excitatory and inhibitory neurons (E/I assemblies), resulting in co-tuning and precise balance of excitation and inhibition. To understand computational consequences of E/I assemblies under biologically realistic constraints we built a spiking network model based on experimental data from telencephalic area Dp of adult zebrafish, a precisely balanced recurrent network homologous to piriform cortex.
View Article and Find Full Text PDFAnal Chem
January 2025
School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, P. R. China.
DNAzyme-based cascade networks are effective tools to achieve ultrasensitive detection of low-abundance miRNAs. However, their designs are complicated and costly, and the operation is time-consuming. Herein, a novel simple noncascade DNAzyme network is designed and its amplification effect is comparable to or even better than many cascading ones.
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