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Factors influencing postoperative urinary retention after radical hysterectomy for cervical cancer: development and validation of a predictive model in a prospective cohort study in Southwest China.
BMJ Open
November 2024
West China School of Nursing, Sichuan University/Department of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Article Synopsis
- The study aims to identify factors influencing postoperative urinary retention (POUR) in cervical cancer patients and develop a prediction model for it.
- It includes a prospective cohort analysis of 1,101 patients undergoing surgery, along with an external validation cohort of 205 patients.
- Key factors found to significantly influence POUR include diabetes, wound healing classification, preoperative treatments, and postoperative infections, leading to a highly accurate prediction model with an AUC of 0.897.
Development and validation of a MRI-radiomics-based machine learning approach in High Grade Glioma to detect early recurrence.
Front Oncol
November 2024
Department of Neurosurgery, Mater Olbia Hospital, Olbia, Italy.
Purpose: Patients diagnosed with High Grade Gliomas (HGG) generally tend to have a relatively negative prognosis with a high risk of early tumor recurrence (TR) after post-operative radio-chemotherapy. The assessment of the pre-operative risk of early versus delayed TR can be crucial to develop a personalized surgical approach. The purpose of this article is to predict TR using MRI radiomic analysis.
View Article and Find Full Text PDFPerioperative Observations and Outcome in Surgical Treatment of Malignant Peripheral Nerve Sheath Tumors.
Cancers (Basel)
November 2024
Department of Neurosurgery, University Hospital Tübingen, BW 72076 Tübingen, Germany.
Background/objectives: This retrospective observational study aimed to investigate the perioperative outcome in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) with and without relation to Neurofibromatosis Type 1 (NF1) and to detect possible influencing factors.
Methods: Clinical reports, histopathological evaluations, imaging, and treatment characteristics were reviewed in 35 operated MPNSTs in 33 patients. Possible predictive valuables included disease type, preoperative tumor volume, SUV and MIB-1 proliferation index, resection margins, the presence of metastasis, and whether radio-/chemotherapy was received.
Randomized clinical trial on accelerated preoperative hyperfractionated radiotherapy versus preoperative hyperfractionated radio-chemotherapy in locally advanced rectal cancer.
Br J Radiol
November 2024
IInd Radiotherapy and Chemotherapy Clinic and Teaching Hospital, Maria Sklodowska-Curie National Research Institute of Oncology, 44-100 Gliwice, Poland.
Objectives: The aim of this study was to compare pathological response rates after preoperative hyperfractionated radiotherapy with co-administration of chemotherapy based on 5FU (HART-CT) versus preoperative hyperfractionated radiotherapy (HART) in patients with resectable rectal cancer.
Methods: Patients with T2/N+ or T3/any N rectal cancer were randomized either to HART twice a day (28 fractions of 1.5 Gy) to total dose 42 Gy or to HART-CT.
Lymphocyte-to-monocyte, platelet-to-albumin and platelet-to-lymphocyte ratios as prognostic biomarkers for neoadjuvant treatment response in rectal cancer patients.
Surg Oncol
October 2024
Department of Medical Oncology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania. Electronic address:
Introduction: Systemic inflammatory response (SIR) indicators are an emerging category of serum biomarkers with significant potential as prognostic and predictive factors in various types of cancers The primary focus of our study was to determine the prognostic value of the lymphocyte-to-monocyte ratio (LMR), platelet-to-albumin ratio (PLR) and platelet-to-albumin ratio (PAR) in evaluating the response to neoadjuvant treatment for patients with rectal cancer.
Materials And Methods: We included 99 consecutive patients with rectal cancer which were admitted for surgery in our institution after completing a standard neoadjuvant radio-chemotherapy regimen. Several hematologic parameters, including LMR, PAR and PLR, were calculated by collecting and analyzing blood samples preoperatively.
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