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Self-Disinfecting Paints with the Natural Antimicrobial Substances: Colophony and Curcumin. | LitMetric

AI Article Synopsis

  • - The study focused on developing self-disinfecting wall paints to reduce infection risks from contaminated surfaces in healthcare settings, using natural antimicrobial agents like colophony and curcumin.
  • - Laboratory tests showed that the paints significantly reduced bacterial growth compared to standard paints, with colophony being particularly effective at lowering bacteria levels.
  • - Safety tests on human cell lines indicated that both paint formulations were non-toxic, showing promising results across multiple cytotoxicity assessment methods.

Article Abstract

The risk of infection arising from indirect sources-namely, contaminated surfaces-has been proved, particularly in healthcare facilities. In the attempt to minimize this problem, innumerable research projects involving the development of surfaces with self-disinfecting properties are being conducted. In this work, wall-paints with self-disinfecting properties were developed with the scope of being applied in environments prone to contamination, such as those at healthcare settings. Our approach was to develop new paint formulations containing two natural plant-based products with known antimicrobial activity-colophony (CLF) and curcumin (CUR). The natural substances were separately incorporated on a commercial paint and their antibacterial activity was evaluated with several bacterial species following ISO 22196. To assess the paints' safety, cytotoxicity tests were performed on HaCaT and A549 cell lines, using tests on extracts and direct contact tests, as suggested by the standardized protocol ISO 10993. In general, both paints containing CLF and CUR were able to reduce the bacterial growth after 24 h, compared with the control, the commercial unmodified paint. Colophony was even able to reduce the number of culturable bacteria by over 2 log for , , and . Regarding the cytotoxicity tests performed (WST-1, NRU, and LDH), both formulations revealed promising results regardless of the methodology used.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615116PMC
http://dx.doi.org/10.3390/antibiotics10111351DOI Listing

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