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Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis.
J Oral Biol Craniofac Res
November 2024
Healthcare and Research, Irvine Medical Center, University of California, Irvine, United States.
Background: Previous studies revealed diabetes mellitus subjects tend to have persistent apical periodontitis. Regenerative stem cells therapy through endodontic procedure is hoped to be a solution. This study assessed bone regeneration in diabetic rats with apical periodontitis through histopathological analysis of osteoblasts and immunohistochemical analysis of runt-related transcription factor 2 (Runx2) and Osterix.
View Article and Find Full Text PDFOrbital Abscess With Vision Threatening Optic Neuropathy Due to Odontogenic Sinusitis in Adolescence: A Case Report and Literature Review.
Cureus
October 2024
Department of Ophthalmology, Hospital Melaka, Melaka, MYS.
Orbital abscesses secondary to odontogenic infections are rare but can lead to serious complications, including compressive optic neuropathy and permanent vision loss, if not diagnosed and treated promptly. We present the case of a 13-year-old child with a radiologically confirmed orbital abscess associated with a recent odontogenic infection. The patient initially presented with a one-week history of right eyelid swelling and fever.
View Article and Find Full Text PDFMesenchymal stem cells from human umbilical cord decrease inflammation and increase vascularization of induced apical periodontitis model in diabetes mellitus rats.
J Appl Oral Sci
October 2024
University of California, Irvine Medical Center, Healthcare and Research, United States of America.
Objectives: to evaluate inflammation and vascularization in a model of apical periodontitis in diabetic Wistar rats through histopathological examination of blood vessels and immunohistochemical examination of interleukin 1b (IL-1b) and tumor necrosis factor-a (TNF-a).
Methodology: Diabetes was induced in 20 Wistar rats using multiple low-dose injections of streptozotocin (STZ) until blood glucose levels stabilized above 300 mg/dL, confirmed by glucometer. Under anesthesia, apical periodontitis was induced in the right mandibular first molars.
Comparison of Antimicrobial Efficacy of , Triphala, and Extracts as Root Canal Irrigants in Primary Molars: A Randomized Clinical Trial.
Int J Clin Pediatr Dent
May 2024
Department of Paediatric and Preventive Dentistry, Rungta College of Dental Sciences and Research, Bhilai, Chhattisgarh, India.
Objective: To evaluate the reduction of microbial loading using , , and as irrigating agents in deciduous molars after pulpectomy.
Materials And Methods: A controlled, randomized clinical trial involving 150 multirooted deciduous molars from both genders between 6 and 9 years old children were included, 30 molars irrigated with (group I), Triphala (group II), (group III), chlorhexidine (CHX) (group IV), and saline (group V) each. In all cases, two microbiological samples from within the canal were taken with sterile paper points, one before the first irrigation and the other immediately after pulp extirpation.
Chemical preconditioning escalates chondrogenic activity in explant cultured human dental pulp stem cell study model for future temporomandibular joint regeneration.
Natl J Maxillofac Surg
July 2024
Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Context: Human dental pulp stem cells (hDPSC) derived from dental pulp in conducive environment activated by chemicals can enhance chondrogenic cells for future animal model temporomandibular joint model.
Aim: The study aims at evaluating the chemicals preconditioning (curcumin and rapamycin) efficacy toward chondrogenic proliferation of human dental pulp stem cells.
Settings And Design: The study model with 10 premolar teeth extirpated pulp was processed under sterile chemical conditions.
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