Recent progress in the oxidative coupling of unactivated Csp-H bonds with other C-H bonds.

Chem Commun (Camb)

Department of Chemistry, Fudan University, 2005 Songhu Rd, Shanghai, 200438, China.

Published: December 2021

AI Article Synopsis

  • - The article discusses the oxidative coupling of carbon-hydrogen (C-H) bonds as a simple and efficient way to create carbon-carbon (C-C) bonds from hydrocarbons without needing any prior modifications.
  • - It highlights recent advancements in coupling unactivated Csp-H bonds with various hybrid C-H bonds, including combinations with Csp-H bonds.
  • - The paper provides a summary of the types of substrates used, proposed reaction mechanisms, and potential applications, aiming to inspire new methods for building Csp-C bonds effectively.

Article Abstract

The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp-H with different hybrid C-H bonds, including Csp-H, Csp-H and Csp-H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp-C bond construction.

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Source
http://dx.doi.org/10.1039/d1cc04802cDOI Listing

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