The oxidative coupling between two carbon-hydrogen (C-H) bonds offers the most straightforward pathway to construct C-C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp-H with different hybrid C-H bonds, including Csp-H, Csp-H and Csp-H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp-C bond construction.
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http://dx.doi.org/10.1039/d1cc04802c | DOI Listing |
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