Aim: In the current study, efforts are being made to prepare Inhalable Silibinin loaded solid lipid nanoparticles (SLNs) with narrow size distribution with improved bioavailability.
Methods: SLNs were formulated by high shear homogenisation method SLNs were characterised, including Differential Scanning Calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR), particle size analysis, entrapment efficiency with Aerodynamic behaviour. The MTT assay was performed against A549 cell line, to measure their anticancer cell activity with study.
Results: Optimized formulation exhibited spherical surface with a mean particle size of 221±1.251nm, PI of 0.121± 0.081, zeta potential of -4.12±0.744. Aerodynamic behaviour such as Mass median aerodynamic diameter (MMAD) and Geometric size distribution (GSD) were found to be 5.487 ± 0.072 and 2.321 ± 0.141 respectively proved formulation is suitable for inhalation. cellular efficacy against A549 cells, revealed that the optimised formulations were more effective and potent.
Conclusion: The Inhalable SLNs approach was successfully engineered and administered to the lungs safely without causing any problems.
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| http://dx.doi.org/10.1080/02652048.2021.2002448 | DOI Listing |
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