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Antenatal Diagnosis and Treatment in Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency and Congenital Adrenal Hyperplasia Screening in Newborns.
J Clin Res Pediatr Endocrinol
January 2025
Marmara University Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey
Signs of virilization, such as clitoromegaly, labio-scrotal fusion, and urogenital sinus may be observed in females with 21-hydroxylase deficiency (21-OHD) and other rare virilizing forms of congenital adrenal hyperplasia (CAH). This makes sex determination difficult, and multiple reconstructive surgeries in the postnatal period may be required. As 21-OHD is an autosomal recessive disease, the chance of any child being affected is one in four and so only one in eight will be an affected female.
View Article and Find Full Text PDFComparative Study of the Safety and Efficacy of Intramuscular Dexamethasone, Betamethasone Phosphate, and Standard Management Protocol in Early-Term Scheduled Caesarean Delivery.
Cureus
September 2024
Obstetrics and Gynaecology, Shri BM Patil Medical College Hospital and Research Centre, Bijapur Lingayat District Educational Association (BLDE) (Deemed to be University), Vijayapura, IND.
Background Babies born between 37 weeks +0 days and 38 weeks +6 days by scheduled caesarean delivery before the onset of labour are more prone to developing respiratory complications than babies delivered between 39 weeks +0 days and 40 weeks +0 days. Antenatal corticosteroids have been used in preterm births for lung maturity. The advantages of administering antenatal corticosteroids before a scheduled caesarean delivery in the early term remain a subject of debate.
View Article and Find Full Text PDFAntenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation.
BMC Med
August 2024
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road NUHS Tower Block, Level 12, Singapore, 119228, Singapore.
Background: Antenatal steroid therapy for fetal lung maturation is routinely administered to women at risk of preterm delivery. There is strong evidence to demonstrate benefit from antenatal steroids in terms of survival and respiratory disease, notably in infants delivered at or below 32 weeks' gestation. However, dosing remains unoptimized and lung benefits are highly variable.
View Article and Find Full Text PDFDoes exogenous glucocorticoid administration during pregnancy precipitate the timing of labor? A scoping review.
Endocr Connect
October 2024
Unit of Endocrinology, Diabetes Mellitus and Metabolism, ARETAIEION University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Article Synopsis
- Researchers looked at how synthetic glucocorticoids (sGCs) given to pregnant women at risk of pre-term labor could affect when they actually go into labor.
- They reviewed many studies and found mixed results; some women gave birth earlier when treated with sGCs while others did not.
- The scientists suggest that sGCs might cause some women to go into labor sooner, but they think more careful research is needed to understand this better.
Effect of Antenatal Corticosteroids in Late Preterm Delivery on Neonatal Respiratory Morbidity: A Randomized Controlled Trial.
Niger Med J
October 2023
Department of Community Medicine, College of Medical Sciences, Ahmadu Bello University Zaria, Nigeria.
Background: The use of antenatal corticosteroids beyond 34 weeks of gestation to prevent certain neonatal complications remains a debate. This study sought to determine the effect of the use of antenatal corticosteroids in late preterm delivery on neonatal morbidity.
Methodology: It was a randomized double-blind placebo and active-controlled multi-arm trial.
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