Background: Carnosic acid (CA) is a polyphenolic diterpene extracted from rosemary. Reports have shown that CA possesses anticancer activity. However, whether CA inhibits esophageal squamous cell carcinoma, an aggressive type of esophageal cancer, remains untested.
Methods: The effects of CA on cell survival, migration, and apoptosis were evaluated by a combination of MTT, colony formation assay, flow cytometry, and Transwell assay. The potential signaling pathways involved were investigated via Western blot assay.
Results: CA dose-dependently inhibited cell proliferation, apoptosis, migration, and colony formation. Mechanistically, CA arrested the cell cycle at G2/M phase, promoted cell apoptosis, induced DNA damage, and inhibited the MAPK signaling pathways.
Conclusion: Our results suggest that CA is a potential anticancer drug for esophageal squamous cell carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610725 | PMC |
| http://dx.doi.org/10.1155/2021/4451533 | DOI Listing |
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