Patients with ovarian cancer and paraneoplastic cerebellar degeneration, a cancer-related immune disorder, often have anti-Yo antibody. Here we studied the distributions of anti-Yo antigens CDR2L and CDR2 in rat and human brain using immunohistochemistry and western blot. CDR2L localized mainly to the Purkinje cells and large neurons scattered in the brain stem. CDR2 was detected in vascular smooth muscle cells of rat and human and in cells lining the ventricle system in rats. The observed distribution of CDR2L is compatible with the hypothesis that this antigen is the major target of anti-Yo. CDR2 and CDR2L are expressed by different cell subtypes.
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| http://dx.doi.org/10.1016/j.jneuroim.2021.577766 | DOI Listing |
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Article Synopsis
- The study explores the relationship between ovarian cancer (OC) and anti-Yo-associated paraneoplastic cerebellar degeneration (PCD), focusing on changes in exosomal microRNA (miRNA) profiles in OC patients with PCD compared to healthy individuals and those without PCD.
- Serum exosomes from three groups (OC with PCD, OC without PCD, and healthy controls) were analyzed, revealing 103 differentially expressed miRNAs in PCD patients versus OC patients without PCD, and 139 versus healthy controls.
- Key miRNAs such as miR-486-5p and miR-21-5p showed potential as biomarkers for diagnosing PCD and indicated a link between these miRNAs and the
Article Synopsis
- The study evaluates the effectiveness of the new EUROLINE Neurologic Syndrome 15 Ag (IgG) test, which adds three new antigens to the existing EUROLINE Paraneoplastic Neurologic Syndrome 12 Ag test.
- The analysis involved testing 194 diagnosed samples and over 100 healthy controls, confirming high sensitivity (89-100%) and specificity (≥99%) for the autoantibodies associated with neurological disorders.
- The findings suggest that this new diagnostic tool can improve the detection of various neuronal autoantibodies, particularly by identifying double positivity for anti-CDR2 and anti-CDR2L, which is linked to paraneoplastic cerebellar degeneration.
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