Influence of Fentanyl, Ketamine, and Lidocaine on Tear Production in Healthy Conscious Dogs.

Top Companion Anim Med

Department of Surgery and Orthopedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, Brno, Czech Republic.

Published: January 2022

Tear production is an important factor in maintaining proper function of the cornea and conjunctiva. The purpose of this study was to determine the effects of bolus followed by infusion of fentanyl, lidocaine, and ketamine on tear production as measured by the Schirmer I Tear Test (STT-I) in dogs. A prospective, randomized, "double-blind" study was performed. A total of 55 healthy conscious client-owned dogs were included in the study. Dogs were randomly allocated to one of four groups and given intravenous fentanyl 0.005 mg kg followed by 0.005 mg kg hour (FEN-group), ketamine 0.6 mg kg followed by 0.6 mg kg hour (KET-group), lidocaine 1 mg kg followed by 1 mg kg hour (LID-group), or saline 0.3 mL kg followed by 2 mL kg hour (SAL-group). The STT-I was performed prior to (baseline) and again 30 minutes (T30) after initiation of drug administration. Data were expressed as the median (minimum - maximum) and analyzed by Wilcoxon and Steel-Dwass tests (P < .05). The STT-I values increased little but were statistically significant in the KET-group from 18 (14-23) to 19 (14-25) (P = .039) and in the LID-group from 21 (14-25) to 20 (17-29) (P = .027). At 30 minutes, STT-I values were significantly higher in LID-group 20 (17-29) than in FEN-group 18 (12-22) (P = .006). Fentanyl, ketamine, and lidocaine administered at the studied doses as a bolus and then followed by an infusion within 30 minutes in healthy conscious dogs demonstrated a clinically insignificant effect on tear production as measured by STT-I.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcam.2021.100615DOI Listing

Publication Analysis

Top Keywords

tear production
16
healthy conscious
12
fentanyl ketamine
8
ketamine lidocaine
8
conscious dogs
8
bolus infusion
8
production measured
8
stt-i values
8
tear
5
dogs
5

Similar Publications

The objective of the study was to examine the mechanical and electrostatic properties of poly(vinyl chloride) intended for use in protective footwear. The poly(vinyl chloride) material was made with graphite (flake side dimensions 5 and 10 µm) additive in weight concentration variants from 0.5 to 10.

View Article and Find Full Text PDF

Dry eye disease (DED) is a multifactorial, chronic, and often relapsing condition with a significant impact on patient quality of life (QoL). Symptoms such as ocular discomfort and visual disturbances are diverse and frequently misaligned with objective clinical signs, complicating diagnosis and management. DED not only interferes with daily activities like reading, driving, and computer use but also imposes a substantial economic burden due to direct healthcare costs and reduced work productivity.

View Article and Find Full Text PDF

Aim: This study aimed to evaluate the impact of a combination of immediate implant placement with maxillary sinus augmentation (MSA) solely using platelet-rich fibrin (PRF) on guided bone regeneration.

Materials And Methods: An interventional before-after (pre-post) study design was used with 30 dental patients (≥18 years of age; 14 males and 16 females) with initial bone heights ranging between 4 and 6 mm. Following the general check-up and the creation of a study model, the planned implant location demonstrated an external right maxilla diameter of more than 5 mm, thereby validating the cone-beam computed tomography (CBCT) radiograph.

View Article and Find Full Text PDF

Calcium alginate reinforced zwitterionic double network hydrogel with mechanical robustness and antimicrobial activity for freshwater shrimp spoilage detection.

Food Res Int

January 2025

Key Laboratory of Product Packaging and Logistics, Packaging Engineering Institute, College of Packaging Engineering, Jinan University, Qianshan Road 206, Zhuhai 519070, Guangdong Province, China. Electronic address:

Hydrogel indicators promise to monitor food spoilage, but their poor mechanics can cause defects in transport. Herein, a novel zwitterionic double network (DN) hydrogel was developed by polymerizing arylamide and sulfobetaine methacrylate in an alginate-Ca system. This hydrogel exhibited enhanced mechanical properties, including a maximum 2087 % breaking elongation and 135 ± 12 kJ/m toughness, significantly outperforming the current zwitterionic DN hydrogels, which typically exhibit less than 1800 % breaking elongation, capable of supporting 150 g-136 times its own weight.

View Article and Find Full Text PDF

May a Single Presurgical High-Field MRI Sequence Replace Standard Radiographs for TPLO Surgical Planning in Dogs?

Vet Radiol Ultrasound

January 2025

Ospedale Veterinario "I Portoni Rossi", Anicura Italy, Diagnostic Imaging Department (Mattei, Specchi), Surgical Department (Pratesi), Neuroradiology Department (Bernardini), Bologna, Italy.

Cranial cruciate ligament (CCL) disease causes variable stifle instability assessed by specific clinical tests. Radiographs are performed to measure the tibial plateau angle (TPA) for planning tibial plateau leveling osteotomy (TPLO) surgery. Concomitant damage to other intra-articular structures, for which clinical detection is unreliable, may occur and potentially affect the surgical outcome.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!