Introduction to Computational Modeling of Multicellular Tissues.

The study of biological tissues is extremely complicated, as they comprise mechanisms and properties at many different temporal and spatial scales. For this reason, modeling is becoming one of the most active and important research fields for the analysis and understanding of tissues. However, this is not a simple task, as it requires mathematical and computational skills, as well as the development of software tools for its implementation. Here, we provide an introduction covering some of the most important and basic issues for modeling tissues. In particular, we focus on both the chemical and cellular properties of a tissue. We explain how to represent and couple these properties within a virtual tissue. All our examples were done using Multicell, a Python library that simplifies their reproducibility, even by readers with little experience in biological modeling.