AI Article Synopsis
- A novel photoelectrochemical (PEC) immunosensor was developed for rapid and sensitive detection of procalcitonin (PCT), a marker for infectious diseases.
- The sensor utilizes a composite made of SnO porous nanoflowers, BiOI nanoflowers, and AgS quantum dots, enhancing signal stability and sensitivity due to their matched energy levels and good light absorption.
- The detection method shows a linear range from 0.50 pg/mL to 100 ng/mL, with a detection limit of 0.14 pg/mL, demonstrating excellent sensitivity, selectivity, stability, and repeatability, which could inform antibiotic therapy practices.
Article Abstract
Based on the necessity and urgency of detecting infectious disease marker procalcitonin (PCT), a novel unlabeled photoelectrochemical (PEC) immunosensor was prepared for the rapid and sensitive detection of PCT. Firstly, SnO porous nanoflowers with good photocatalytic performance were prepared by combining hydrothermal synthesis and calcining. BiOI nanoflowers were synthesized by facile ultrasonic mixed reaction. AgS quantum dots were deposited on SnO/BiOI composites by in situ growth method. The SnO/BiOI/AgS composites with excellent photoelectric properties were employed as substrate material, which could provide significantly enhanced and stable signal because of the energy level matching of SnO, BiOI and AgS and the good light absorption performance. Accordingly, a PEC immunosensor based on SnO/BiOI/AgS was constructed by using the layered modification method to achieve high sensitivity analysis of PCT. The linear dynamic range of the detection method was 0.50 pg·mL~100 ng·mL, and the detection limit was 0.14 pg·mL. In addition, the designed PEC immunosensor exhibited satisfactory sensitivity, selectivity, stability and repeatability, which opened up a new avenue for the analyzation of PCT and further provided guidance for antibiotic therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615900 | PMC |
| http://dx.doi.org/10.3390/bios11110421 | DOI Listing |
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