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The Effect of Haematocrit on Measurement of the Mid-Infrared Refractive Index of Plasma in Whole Blood. | LitMetric

AI Article Synopsis

  • Recent advancements in miniaturized mid-infrared (MIR) devices may simplify clinical diagnostics by replacing traditional lab methods.
  • The research utilized Fourier transform infrared spectroscopy to analyze how the MIR refractive index of whole blood changes with varying levels of haematocrit, indicating that previously thought evanescent measurements can't fully eliminate the blood's cellular content.
  • The findings reveal a maximum error of 0.25% in the effective plasma refractive index due to healthy adults' haematocrit, suggesting that calibrations can adjust for these errors, allowing for direct analysis of plasma concentrations and drugs from whole blood samples.

Article Abstract

Recent advances suggest that miniaturised mid-infrared (MIR) devices could replace more time-consuming, laboratory-based techniques for clinical diagnostics. This work uses Fourier transform infrared spectroscopy to show that the MIR complex refractive index of whole blood varies across a range of haematocrit. This indicates that the use of an evanescent measurement is not sufficient to optically exclude the cellular content of blood in the MIR, as previously assumed. Here, spectral refractive index data is presented in two ways. First, it is given as whole blood with varying haematocrit. Second, it is given as the percentage error that haematocrit introduces to plasma. The maximum error in the effective plasma refractive index due to the haematocrit of healthy adults was 0.25% for the real part n and 11% for the imaginary part k. This implies that calibration measurements of haematocrit can be used to account for errors introduced by the cellular content, enabling plasma spectra and analyte concentrations to be indirectly calculated from a whole blood sample. This methodological advance is of clinical importance as plasma concentration of analytes such as drugs can be determined using MIR without the preprocessing of whole blood.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616018PMC
http://dx.doi.org/10.3390/bios11110417DOI Listing

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