AI Article Synopsis
- Hepatocellular carcinoma (HCC) is a highly lethal cancer with limited treatment options and a poor 5-year survival rate of less than 20%.
- Researchers identified 58 pyroptosis-related genes (PRGs) and created a six-gene risk model that helps classify HCC patients into high and low-risk groups based on survival outcomes.
- The study suggests that PRGs could serve as prognostic indicators for HCC, and targeting pyroptosis may offer new therapeutic strategies for patients.
Article Abstract
Hepatocellular carcinoma (HCC) is the second most lethal malignant tumor worldwide, with an increasing incidence and mortality. Due to general resistance to antitumor drugs, only limited therapies are currently available for advanced HCC patients, leading to a poor prognosis with a 5-year survival rate less than 20%. Pyroptosis is a type of inflammation-related programmed cell death and may become a new potential target for cancer therapy. However, the function and prognostic value of pyroptosis-related genes (PRGs) in HCC remain unknown. Here, we identified a total of 58 PRGs reported before and conducted a six-PRG signature the LASSO regression method in the GEO training cohort, and model efficacy was further validated in an external dataset. The HCC patients can be classified into two subgroups based on the median risk score. High-risk patients have significantly shorter overall survival (OS) than low-risk patients in both training and validation cohorts. Multivariable analysis indicated that the risk score was an independent prognostic factor for OS of HCC patients. Functional enrichment analysis and immune infiltration evaluation suggested that immune status was more activated in the low-risk group. In summary, PRGs can be a prediction factor for prognosis of HCC patients and targeting pyroptosis is a potential therapeutic alternative in HCC.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606528 | PMC |
| http://dx.doi.org/10.3389/fcell.2021.742994 | DOI Listing |
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