Antihypertensive Activity of Combination of (Ten.) V. Steenis and L. Leaves on Epinephrine Induced Male Wistar Rat.

In Indonesia, hypertension is a condition that can lead to death through stroke and TB. Herbs have traditionally been used in Indonesia as an alternative medicine for lowering blood pressure. The leaves of and have been investigated for their antihypertensive potential. Based on the number of treatments, rats were randomized into groups. Each group consists of five rats. The test animals were grouping as follows: the positive control group (hypertension induction without treatment), 50 mg/kg b.w. group, 100 mg/kg b.w., 50 mg/kg b.w, 100 mg/kg b.w., 25 mg/kg b.w + 25 mg/kg b.w, 50 mg/kg b.w + 50 mg/kg b.w, and atenolol 4.5 mg/kg b.w. The rats were given 0.25 mg/kg b.w. of epinephrine intraperitoneally. The initial, after induction, and final blood pressure of the animals were measured using the CODA noninvasive blood pressure device. All animal test groups at T60 showed a significant difference in systolic and diastolic blood pressures to initial blood pressure (T0), < 0.05. The combination of 50 mg/kg b.w and 50 mg/kg b.w showed the highest percent inhibition of systolic and diastolic blood pressure. The combination of and 50-50 mg/kg b.w showed the best effect of lowering systolic and diastolic blood pressure on the pathway of inhibiting adrenergic receptors.