In photosensitizers, long triplet excited state lifetimes are key to their efficient electron transfer or energy transfer processes. Herein, we report a novel class of cyclic trimeric BODIPY arrays which were efficiently generated from easily accessible -mesityldipyrrinone and arylboronic acids in one pot. Arylboronic acid, for the first time, was used to provide a boron source for BODIPY derivatives. Due to the well-defined and orthogonally aligned BODIPY cores as verified by X-ray crystallography, these BODIPY arrays show strong exciton coupling effects and efficient intersystem crossings, and are novel heavy-atom-free photosensitizers with a long-lived triplet excited state (lifetime up to 257.5 μs) and good reactive oxygen species generation efficiency (up to 0.72) contributed by both O and O ˙ under light irradiation.
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http://dx.doi.org/10.1039/d1sc04893g | DOI Listing |
Stem Cell Res Ther
December 2024
Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immunomodulation, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.
Background: Human platelet lysate (hPL) has emerged as a promising serum substitute to enhance the self-renewal and multipotency of human mesenchymal stem cells (MSCs). Despite its potential, the specific biological mechanisms by which hPL influences MSC phenotypes remain inadequately understood.
Methods: We investigated the biological signaling activated by hPL in two common types of human MSCs: bone marrow-derived MSCs (BMSCs) and adipose-derived MSCs (ASCs).
Biosens Bioelectron
February 2025
Department of Chemical Sciences, University of Catania, viale A. Doria 6, 95125, Catania, Italy; INSTM Udr of Catania, Viale Andrea Doria 6, 95125, Catania, Italy. Electronic address:
Inorg Chem
December 2024
Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996, United States.
We have prepared and characterized two diradicaloid systems and that originated from the oxidation of a 1,7-(4-(2,6-di--butyl)phenol)-substituted aza-BODIPY core. The aza-BODIPY diradicaloids were characterized by a large array of experimental and computational methods. The diamagnetic closed-shell state was postulated as the ground state in solution and a solid-state with the substantial thermal population originating from both open-shell diradical and open-shell triplet states observed at room temperature.
View Article and Find Full Text PDFACS Org Inorg Au
October 2024
Department of Chemistry and Molecular Biology, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Medicinaregatan 7B, Gothenburg 413 90, Sweden.
Labeling of peptides and proteins with fluorescent dyes is a key step in functionalizing these structures for a wide array of biological assays. However, coupling strategies of such dyes have not been optimized for the most common compounds, while this step is typically the most precious and costly of the whole synthesis. We searched for the best conditions for attachment of the most widely used fluorescent dyes such as 6-carboxyfluorescein, Rhodamine B, and BODIPY-FL to peptides, where amino terminal Cu(II) and Ni(II) binding site (ATCUN) peptides were used as a model system.
View Article and Find Full Text PDFChem Sci
July 2024
Universität Münster, Organisch-Chemisches Institut Corrensstraße 36 Münster 48149 Germany
In controlled supramolecular polymerization, planar π-conjugated scaffolds are commonly used to predictably regulate stacking interactions, with various assembly pathways arising from competing interactions involving side groups. However, the extent to which the nature of the chromophore itself (planar non-planar) affects pathway complexity requires clarification. To address this question, we herein designed a new BOPHY dye 2, where two oppositely oriented BF groups induce a disruption of planarity, and compared its supramolecular polymerization in non-polar media with that of a previously reported planar BODIPY 1 bearing identical substituents.
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