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Working memory (WM) is an evolving concept. Our understanding of the neural functions that support WM develops iteratively alongside the approaches used to study it, and both can be profoundly shaped by available tools and prevailing theoretical paradigms. Here, the organizers of the 2024 Working Memory Symposium-inspired by this year's meeting-highlight current trends and looming questions in WM research.
View Article and Find Full Text PDFMapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma.
Nat Cell Biol
January 2025
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Glioblastoma (GBM) is defined by heterogeneous and resilient cell populations that closely reflect neurodevelopmental cell types. Although it is clear that GBM echoes early and immature cell states, identifying the specific developmental programmes disrupted in these tumours has been hindered by a lack of high-resolution trajectories of glial and neuronal lineages. Here we delineate the course of human astrocyte maturation to uncover discrete developmental stages and attributes mirrored by GBM.
View Article and Find Full Text PDFCardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis.
BMJ Open Gastroenterol
January 2025
Inflammatory Bowel Disease Center and Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Objective: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.
View Article and Find Full Text PDF[Textual research on ancient geo-authentic producing areas of Chaenomeles speciosa based on literature and historical records from materia medica and local chronicles].
Zhongguo Zhong Yao Za Zhi
October 2024
School of Pharmacy, Anhui University of Traditional Chinese Medicine Hefei 230012, China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China Key Scientific Research Base of Traditional Chinese Medicine Heritage (Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences), National Cultural Heritage Administration Beijing 100700, China.
Chaenomeles speciosa, a commonly used traditional Chinese medicine(TCM) material, has the effects of stimulating the circulation of the blood and causing the muscles and joints to relax, as well as harmonizing the stomach and resolving dampness. It was first recorded in the Ming Yi Bie Lu during the Northern and Southern Dynasties, and its cultivation history can be traced back to the Bencao Tujing in the Song Dynasty. Modern research mainly focuses on the producing areas of Ch.
View Article and Find Full Text PDFFrom Doubt to Confidence-Overcoming Fraudulent Submissions by Bots and Other Takers of a Web-Based Survey.
J Med Internet Res
December 2024
Institute for Global Tobacco Control, Department of Health, Behavior and Society, Johns Hopkins University, Baltimore, MD, United States.
In 2019, we launched a web-based longitudinal survey of adults who frequently use e-cigarettes, called the Vaping and Patterns of E-cigarette Use Research (VAPER) Study. The initial attempt to collect survey data failed due to fraudulent survey submissions, likely submitted by survey bots and other survey takers. This paper chronicles the journey from that setback to the successful completion of 5 waves of data collection.
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