AI Article Synopsis
- A cytochrome P-450 gene family (CYP1), which is influenced by phenobarbitone, is located on chromosome 19q13.1-qter.
- Researchers used a human liver cDNA probe to perform in situ hybridization on metaphase chromosomes from two individuals with balanced translocations involving chromosome 19.
- The findings indicated a more specific regional location for the CYP1 gene family on chromosome 19q13.1-13.3.
Article Abstract
A phenobarbitone inducible cytochrome P-450 gene family (CYP1) has recently been localized to chromosome 19q13.1-qter. We have used a human liver cDNA probe in in situ hybridization experiments to metaphase chromosomes from two balanced translocation carriers, 46,XX,t(11;19) (q13;q13.1) and 46,XX,t(7;19) (q31.3;q13.3) to obtain a more precise localization. The results suggest a regional assignment for CYP1 to chromosome 19q13.1-13.3.
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| http://dx.doi.org/10.1111/j.1469-1809.1986.tb01044.x | DOI Listing |
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