AI Article Synopsis
- We investigated brain activity using fMRI and iEEG in 29 neurosurgical patients with implanted electrodes, focusing on how different brain networks communicate over time.
- We stimulated and recorded responses from over 4,500 brain sites, identifying that certain response segments (N1 and N2) correspond to communication within and between brain networks.
- Our findings indicate that the brain processes information within networks before it communicates between them, all at very fast timescales (less than a second).
Article Abstract
We studied the temporal dynamics of activity within and across functional MRI (fMRI)-derived nodes of intrinsic resting-state networks of the human brain using intracranial electroencephalography (iEEG) and repeated single-pulse electrical stimulation (SPES) in neurosurgical subjects implanted with intracranial electrodes. We stimulated and recorded from 2,133 and 2,372 sites, respectively, in 29 subjects. We found that N1 and N2 segments of the evoked responses are associated with intra- and internetwork communications, respectively. In a separate cognitive experiment, evoked electrophysiological responses to visual target stimuli occurred with less temporal separation across pairs of electrodes that were located within the same fMRI-defined resting-state networks compared with those located across different resting-state networks. Our results suggest intranetwork prior to internetwork information processing at the subsecond timescale.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640784 | PMC |
| http://dx.doi.org/10.1073/pnas.2105031118 | DOI Listing |
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