It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling.

PLoS Biol

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

Published: November 2021

Synaptic scaling allows neurons to adjust synaptic strength in response to chronic alterations in neuronal activity. A new study in PLOS Biology identifies a pathway that synergizes protein synthesis and degradation with remodeling of the microRNA (miRNA)-induced silencing complex (miRISC) to mediate synaptic scaling.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8612543PMC
http://dx.doi.org/10.1371/journal.pbio.3001448DOI Listing

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