An iron-catalysed C-H functionalisation of simple monosubstituted allenes for the synthesis of 1-tetrahydroisoquinolinyl 1,1-disubstituted allenes is reported. This transformation represents the first example of a direct conversion of allenic C-H bonds to C-C bonds through cross dehydrogenative coupling. The optimized protocol features broad scope and employs mild, functional group tolerant conditions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8665127 | PMC |
| http://dx.doi.org/10.1039/d1cc05949a | DOI Listing |
Publication Analysis
Top Keywords
contrasteric coupling
4
coupling allenes
4
allenes tetrahydroisoquinolines
4
tetrahydroisoquinolines iron-catalysed
4
iron-catalysed allenic
4
allenic csp-h
4
csp-h functionalisation
4
functionalisation iron-catalysed
4
iron-catalysed c-h
4
c-h functionalisation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!