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-Selective hydroxylation of alkyl aryl ethers. | LitMetric

-Selective hydroxylation of alkyl aryl ethers.

Chem Commun (Camb)

School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, People's Republic of China.

Published: December 2021

-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

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Source
http://dx.doi.org/10.1039/d1cc06210gDOI Listing

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