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Post-irradiation Sinus Mucosa Disease in Nasopharyngeal Carcinoma Patients Treated With Proton Therapy.
Laryngoscope
December 2024
Division of Rhinology, Department of Otolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Objective: Post-irradiation sinonasal mucosa disease (SMD) is observed in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy (RT), leading to a detrimental impact on quality of life. This study aimed to assess the incidence, severity, and regression of the post-irradiation SMD among patients with NPC treated with proton therapy.
Methods: NPC patients treated with proton therapy were retrospectively enrolled.
Development of patient-specific pre-treatment verification procedure for FLASH proton therapy based on time resolved film dosimetry.
Med Phys
November 2024
HollandPTC, Delft, The Netherlands.
Background: Pre-clinical studies demonstrate that delivering a high dose at a high dose rate result in less toxicity while maintaining tumor control, known as the FLASH effect. In proton therapy, clinical trials have started using 250 MeV transmission beams and more trials are foreseen. A novel aspect of FLASH treatments, compared to conventional radiotherapy, is the importance of dose rate next to dose and geometry.
View Article and Find Full Text PDFRisk factors of post-irradiation carotid blowout syndrome in patients with nasopharyngeal carcinoma.
Support Care Cancer
October 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Shipai Rd, No. 201, Sec. 2, Taipei, 11217, Taiwan.
Article Synopsis
- The study focuses on carotid blowout syndrome (CBS), a serious complication in nasopharyngeal carcinoma (NPC) patients after radiotherapy.
- Researchers analyzed data from 660 NPC patients and identified 17 cases of CBS, discovering that lower BMI, tumor encasement, local recurrence, and skull base osteoradionecrosis are significant risk factors.
- The findings suggest that recognizing these predictors can aid physicians in the early detection and prevention of CBS in NPC patients.
Post-irradiation darkening model for EBT-3 films characterized using a single lot calibration approach.
Phys Med Biol
October 2024
Department of Radiation Oncology, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium.
In this study, we present a model to correct the progressive post-irradiation darkening of EBT3 films. The model allows for a clinical use of EBT3 using application and calibration films scanned with different post-irradiation times.The model is a post-irradiation time- and dose-dependent power-law function, projecting the scanned transmittance of application films to the transmittance matching the same post-irradiation time of calibration films.
View Article and Find Full Text PDFCaloric Restriction Diet Attenuates Systemic Bone Fragility after Radiotherapy.
Radiat Res
November 2024
Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, New York.
Bone fragility is a well-documented long-term side effect of radiotherapy, which currently has no preventative treatments. In this study, we applied a caloric restriction (CR) diet to attenuate both local and systemic bone loss after irradiation (RTx) in an established female Balb/c mouse model (4 consecutive daily doses of 5 Gy to the right hindlimb only). CR mice were tapered down to a 30% reduced calorie diet (RTx/CR) one week before irradiation, while regular diet (RD) mice received food ad libitum (RTx/RD).
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