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| http://dx.doi.org/10.1136/emermed-2021-212076 | DOI Listing |
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Sex and Gender Considerations in Orthopaedic Research: Existing Barriers, What's Needed by Institutions and Research Departments, and How to Guide Junior Investigators and Faculty.
J Bone Joint Surg Am
October 2024
Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland.
Article Synopsis
- The JBJS symposium focused on the importance of including sex and gender in orthopaedic research to enhance study methods and patient outcomes, addressing current shortcomings in reporting.
- Barriers to proper reporting stem from cultural resistance, inadequate education on terminology and study design, insufficient funding for larger studies, and the need for better understanding of how biological and social factors like gender and race interact in health research.
- To overcome these challenges, the development of best-practice statistical methods and ongoing education for all stakeholders in research is crucial, with existing guidelines like the SAGER providing a framework for improvement and support from academic institutions and funders being essential for meaningful progress.
Procedural and clinical outcomes of Adiana® hysteroscopic tubal occlusion in the Netherlands.
Facts Views Vis Obgyn
December 2024
Background: The Adiana® Permanent Contraception System was a hysteroscopic tubal occlusion device but was withdrawn from the market in 2012.
Objective: To evaluate the safety, feasibility and efficacy of the Adiana hysteroscopic tubal occlusion.
Materials And Methods: A prospective observational multicentre cohort study of 300 women undergoing hysteroscopic sterilisation using the Adiana® was conducted in the Netherlands between 2009 and 2012.
Promising therapeutic strategies for Lennox-Gastaut syndrome: what's new?
Expert Rev Neurother
January 2025
Department of Paediatrics, Cambridge University Hospitals, Cambridge, UK.
Introduction: The seizures in Lennox-Gastaut syndrome are typically resistant to treatment. Seven antiseizure medications (ASMs) in the US (six in the UK/EU) are licensed for the treatment of seizures in LGS: lamotrigine, topiramate, rufinamide, clobazam, felbamate (not licensed in the UK/EU), cannabidiol and fenfluramine. Other options include neurostimulation, corpus callosotomy and dietary therapies, principally the ketogenic diet and its variants.
View Article and Find Full Text PDFNovel NIR fluorescent probe based on BODIPY for diagnosis and treatment evaluation of alcoholic liver disease via visualizing HClO fluctuation.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Key Laboratory for Special Functional Materials of Ministry of Education, School of Nanoscience and Materials Engineering, Henan University, Kaifeng 475004, PR China. Electronic address:
Alcoholic liver disease (ALD) is gradually becoming common due to the increasing number of drinkers worldwide, which is a serious threat to human physical and mental health. In the process of ALD, it is often accompanied by the occurrence of inflammation, which induce high expression of reactive oxygen species including HClO. In this work, we successfully fabricated a NIR fluorescent probe BDP-ENE-Fur-HClO for real-time imaging alcoholic liver disease via tracing HClO.
View Article and Find Full Text PDFWhat's (Not) in Your Supplement? An Energy and Macronutrient Analysis of Commercially Available Carbohydrate Gels.
Int J Sport Nutr Exerc Metab
November 2024
Independent Consultant.
Carbohydrate (CHO) gels are a staple among endurance athletes. When ingested during competition, CHO gels can improve endurance performance by acting as an external energy substrate, sparing endogenous glycogen, mitigating the risk of hypoglycemia, and engaging the central nervous system via receptors in the mouth and gastrointestinal tract. However, published studies and a growing number of anecdotal reports have raised concerns about possible energy and macronutrient deficiencies in several products.
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