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Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.
Hematology
December 2022
Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Background: The appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels. Bite cells are often pathognomonic for oxidant injury in patients with G6PD deficiency and suggest active hemolysis.
Case Presentation: We report a case of a woman with no prior history of G6PD deficiency who presented with anemia, methemoglobinemia and bite cells on peripheral blood smear after dapsone therapy for new onset idiopathic urticaria.
New-Onset Methemoglobinemia After Receiving Ozone Autohemotherapy and High-Dose Vitamin C Injection.
Transfus Med Rev
January 2022
Department of Emergency and Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Kaohsiung Medical University, Kaohsiung city, Taiwan; School of Medicine, Chung Shan Medical University, Taichung city, Taiwan; College of Medicine, National Chung Hsing University, Taichung city, Taiwan. Electronic address:
Methemoglobinemia in a 14-year-old girl with new-onset dyspnea.
JAAPA
December 2019
Michelle Wallace is an associate clinical professor and research coordinator at Wichita State University and practices in the pediatric ED at Wesley Medical Center, both in Wichita, Kan. Caitlin Tenbarge practices at Franciscan Express Care in Indianapolis, Ind. Sofia Harlow practices at Pain & Spine Centers of Florida in Leesburg and Lady Lake, Fla. Nathan Kasting practices at Salina (Kans.) Regional Sports Medicine & Orthopedics. Justin Gooden practices in the pediatric ED at Wesley Medical Center in Wichita, Kans. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Methemoglobinemia is a rare and potentially life-threatening medical emergency that can be overlooked when evaluating a patient in respiratory distress. Without early recognition, patients may develop respiratory failure and die. This article describes a teenager who presented to the ED for dyspnea and lightheadedness and failed to respond to supplemental oxygen.
View Article and Find Full Text PDFHemolysis and methemoglobinemia secondary to rasburicase administration.
Ann Pharmacother
November 2005
Department of Pharmacy Services, Detroit Receiving Hospital, Detroit Medical Center, Detroit, MI 48201-2403, USA.
Objective: To report a case of hemolytic anemia and methemoglobinemia developing after rasburicase administration to a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Case Summary: A 50-year-old African American man was hospitalized with new onset seizure, diabetic ketoacidosis, respiratory failure, and acute renal failure. Serum uric acid concentrations were elevated, and the patient was treated with one dose of intravenous rasburicase 22.
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